Postoperative Ileus Murine ModelDan Tian *1,2,3,4,5, Bihan Liu *1,2,3,4,5, Shiyang Huang 2,3,4,5,6, Wen Shi 2,3,4,5,6, Yue Tian 2,3,4,5,6, Yingchi Yang 1,2,3, Dong Zhang 7,8, Zhongtao Zhang 1,2,3, Fandi Bu 9
1General Surgery Department, Beijing Friendship Hospital, Capital Medical University, 2National Clinical Research Center for Digestive Diseases, 3State Key Lab of Digestive Health, Beijing Friendship Hospital, Capital Medical University, 4Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, 5Beijing Laboratory of Oral Health, Capital Medical University School of Stomatology, 6Beijing Clinical Research Institute, 7Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, 8Beijing Institute of Brain Disorders, Capital Medical University, 9Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University
We describe a murine model of postoperative ileus generated via intestinal manipulation. Gastrointestinal transit function, pathologic changes, and immune cell activation were assessed 24 h after surgery.
