Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal ModelBryan D. Kim 1,2, Sujan K. Mondal 1,3, Elizabeth Kenyon 1,3, Ming Chen 1,3, Christiane L. Mallett 3,4, Ana C. deCarvalho 5, Zdravka Medarova 6, Anna Moore 1,3
1Precision Health Program, Michigan State University, 2Department of Biomedical Engineering, College of Engineering, Michigan State University, 3Department of Radiology, College of Human Medicine, Michigan State University, 4Institute for Quantitative Health Science and Engineering, Michigan State University, 5Henry Ford Health, 6Transcode Therapeutics Inc.
The blood-brain barrier is a significant hurdle in the delivery of therapies for glioblastoma, a disease for which there is no cure. Here, we report an in vivo image-guided iron oxide therapeutic nano platform that can bypass this physiological barrier by virtue of size and accumulate in the tumor.
