Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse ModelJaesung P. Choi 1,2, Xi Yang 3, Matthew Foley 4, Xian Wang 1, Xiangjian Zheng 1,2,3
1Lab of Cardiovascular Signaling, Centenary Institute, 2Faculty of Medicine, Sydney Medical School, University of Sydney, 3Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, 4Australian Centre for Microscopy & Microanalysis, University of Sydney
This protocol demonstrates the induction of cerebral cavernous malformation disease in a mouse model and uses contrast enhanced micro computed tomography to measure lesion burden. This method enhances the value of established mouse models to study the molecular basis and potential therapies for cerebral cavernous malformation and other cerebrovascular diseases.
