Pre-clinical Orthotopic Murine Model of Human Prostate CancerVarahram Shahryari 1, Hannah Nip 1, Sharanjot Saini 1, Altaf A. Dar 2, Soichiro Yamamura 1, Yozo Mitsui 1, Melissa Colden 1, Nathan Bucay 1, Laura Z. Tabatabai 1, Kirsten Greene 1, Guoren Deng 1, Yuichiro Tanaka 1, Rajvir Dahiya 1, Shahana Majid 1
1Department of Urology, VA Medical Center and UCSF, 2California Pacific Medical Center Research Institute
Prostate cancer is the second most common cause of cancer-related deaths in the United States. An orthotopic cancer model provides a useful approach to understand the biology of prostate cancer and to evaluate the efficacy of therapeutic regimens. This protocol describes detailed steps necessary to establish an orthotopic prostate cancer mouse model.
