Hamburg University of Technology

4 ARTICLES PUBLISHED IN JoVE

Neuroscience

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Nicole Brazda^*1, Veronica Estrada^*1, Christian Voss^2,3, Klaus Seide³, Hoc Khiem Trieu², Hans Werner Müller¹

¹Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University Medical Center, ²Institute of Microsystems Technology, Hamburg University of Technology, ³Biomechanical Laboratory, BG Trauma Center Hamburg

Severe spinal cord injuries often result in tissue defects. Two possibilities are described to successfully bridge such gaps to promote tissue adaptation, regenerative responses and functional improvement in rats via implantation of a mechanical microconnector system after acute injury and five weeks after complete spinal cord transection.

Chemistry

Preparation of Biopolymer Aerogels Using Green Solvents

Raman Subrahmanyam¹, Pavel Gurikov¹, Imke Meissner¹, Irina Smirnova¹

¹Institute of Thermal Separation Processes, Hamburg University of Technology

A new way for the production of biopolymer-based aerogels by carbon dioxide (CO₂) induced gelation is shown. The technique utilizes pressurized carbon dioxide (5 MPa) for the production of biopolymer hydrogels and supercritical CO₂ (12 MPa) to convert gels into aerogels. The only solvents needed besides CO₂ are water and ethanol.

Bioengineering

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Hao-Hsiang Hsu¹, John-Kevin Kracht¹, Laura Elisabeth Harder¹, Kerstin Rudnik¹, Gerd Lindner², Katharina Schimek², Uwe Marx³, Ralf Pörtner¹

¹Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, ²Institute of Biotechnology, Department Medical Biotechnology, Technische Universität Berlin, ³TissUse GmbH

A method for determination of permeability in a membrane insert system for multi-well plates and in silico parameter optimization for the calculation of diffusion coefficients using simulation are presented.

Engineering

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot

Lars Schiller¹, Arthur Seibel², Josef Schlattmann¹

¹Workgroup on System Technologies and Engineering Design Methodology, Hamburg University of Technology, ²Fraunhofer Research Institution for Additive Manufacturing Technologies IAPT

This protocol provides a detailed list of steps to be performed for the manufacturing, control and evaluation of the climbing performance of a gecko-inspired soft robot.