Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic ApproachSaleta Sierra 1, Rolf Kaiser 1, Nadine Lübke 1, Alexander Thielen 2, Eugen Schuelter 1, Eva Heger 1, Martin Däumer 3, Stefan Reuter 4, Stefan Esser 5, Gerd Fätkenheuer 6, Herbert Pfister 1, Mark Oette 7, Thomas Lengauer 2
1Institute of Virology, University of Cologne, 2Max Planck Institute for Informatics, 3Institute for Immune genetics, 4Department of Gastroenterology, Hepatology and Infectiology, University of Duesseldorf, 5Department of Dermatology, University of Essen, 6Department of Internal Medicine, University of Cologne, 7Augustinerinnen Hospital
The prediction of the coreceptor usage of HIV-1 is required for the administration of a new class of antiretroviral drugs, i.e. coreceptor antagonists. It can be performed by sequence analysis of the env gene and subsequent interpretation through an internet based interpretation system (geno2pheno[coreceptor]).
