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University of Bonn, Germany

5 ARTICLES PUBLISHED IN JoVE

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Medicine

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
Se-Chan Kim 1, Olaf Boehm 1, Rainer Meyer 2, Andreas Hoeft 1, Pascal Knüfermann 1, Georg Baumgarten 1
1Department of Anesthesiology and Intensive Care Medicine, University of Bonn, Germany, 2Institute of Physiology, University of Bonn, Germany

Surgical trauma induces an inflammatory response. Cytokines and endogenous ligands are known to modulate myocardial infarct size following ischemia and reperfusion. We present a modified closed-chest model of murine ischemia and reperfusion using hanging weights to minimize effects of thoracotomy.

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Medicine

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
Tim O. Vilz 1, Marcus Overhaus 1, Burkhard Stoffels 1, Martin von Websky 1, Joerg C. Kalff 1, Sven Wehner 1
1Department of Surgery, University of Bonn

Postoperative ileus (POI) is a complication of abdominal surgery leading to increased morbidity and a prolonged hospital stay. Because prophylactic or therapeutic strategies are lacking intensified research is necessary. Therefore we established a standardized and feasible mouse model to investigate the pathophysiology of POI and to study potential therapeutic options.

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Medicine

Orthotopic Small Bowel Transplantation in Rats
Koji Kitamura *1,2, Martin W. von Websky *1, Ichiro Ohsawa 1, Azin Jaffari 1, Thomas C. Pech 1, Tim Vilz 1, Sven Wehner 1, Shinji Uemoto 2, Joerg C. Kalff 1, Nico Schaefer 1
1Department of Surgery, University of Bonn, Germany, 2Department of Surgery, Kyoto University Hospital

Small bowel transplantation has become an accepted treatment option for patients with irreversible intestinal failure. Our experimental model of orthotopic small bowel transplantation in rats serves as a reliable tool to address underlying immunologic and inflammatory processes that complicate intestinal transplantation.

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Medicine

The Supraclavicular Fossa Ultrasound View for Central Venous Catheter Placement and Catheter Change Over Guidewire
Se-Chan Kim 1, Christian Klebach 1, Ingo Heinze 1, Andreas Hoeft 1, Georg Baumgarten 1, Stefan Weber 1
1Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn

The overall goal is to enable clinicians to insert a central venous catheter under real-time ultrasound guidance via the right supraclavicular fossa view of the lower part of the superior vena cava. This view is useful for different catheter insertion sites, thrombosis detection before insertion and ultrasound guided correction of misplaced catheters.

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Medicine

A Model to Simulate Clinically Relevant Hypoxia in Humans
Lars Eichhorn 1, Florian Kessler 1, Volker Böhnert 2, Felix Erdfelder 1, Anja Reckendorf 3, Rainer Meyer 4, Richard K. Ellerkmann 1
1Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Bonn, 2Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, 3Institute for Terrestrial and Aquatic Wildlife Research, University of Veterinary Medicine Hannover, 4Institute of Physiology 2, University of Bonn

Hypoxia simulation in humans has usually been performed by inhaling hypoxic gas mixtures. For this study, apneic divers were used to simulate dynamic hypoxia in humans. Additionally, physiological changes in desaturation and re-saturation kinetics were evaluated with non-invasive tools such as Near-Infrared-Spectroscopy (NIRS) and peripheral oxygenation saturation (SpO2).

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