Whole-Body Nanoparticle Aerosol Inhalation ExposuresJinghai Yi 1,2, Bean T. Chen 3, Diane Schwegler-Berry 3, Dave Frazer 3, Vince Castranova 3, Carroll McBride 1, Travis L. Knuckles 1,2, Phoebe A. Stapleton 1,2, Valerie C. Minarchick 1,2, Timothy R. Nurkiewicz 1,2
1Department of Physiology and Pharmacology, School of Medicine, West Virginia University , 2Center for Cardiovascular and Respiratory Sciences, West Virginia University , 3National Institute for Occupational Safety and Health
A whole-body nanoparticle aerosol inhalation exposure facility was constructed for nano-sized titanium dioxide (TiO2) inhalation toxicology studies. This system provides nano-TiO2 aerosol test atmospheres that have: 1) a steady mass concentration; 2) a homogenous composition free of contaminants; and 3) a stable particle size distribution during aerosol generation.
