Lavage-induced Surfactant Depletion in Pigs As a Model of the Acute Respiratory Distress Syndrome (ARDS)Martin Russ 1, Sebastian Kronfeldt 1, Willehad Boemke 1, Thilo Busch 2, Roland C. E. Francis *1, Philipp A. Pickerodt *1
1Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Charité - Universitätsmedizin, Berlin, 2Department of Anesthesiology and Intensive Care Medicine, University of Leipzig Medical Faculty
Repeated pulmonary lavages in anesthetized pigs induce lung injury resembling major aspects of human acute respiratory distress syndrome (ARDS). For this purpose the lungs are repeatedly lavaged with 0.9% saline at 37 °C. The goal of the protocol is a reproducible mitigation of gas exchange and hemodynamics for research in ARDS.
