Institute of Oncology Ljubljana
2 ARTICLES PUBLISHED IN JoVE
Biology
Electrochemotherapy of Tumours
Gregor Sersa 1, Damijan Miklavcic 2
1Department of Experimental Oncology, Institute of Oncology Ljubljana, 2Faculty of Electrical Engineering, University of Ljubljana
Electrochemotherapy is a combined use of certain chemotherapeutic drugs such as cisplatin and bleomycin and electric pulses applied to the treated tumour nodule. We present the clinical protocol of electrochemotherapy for treatmen of subcutaneous and cutaneous metastases of melanoma.
Cancer Research
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
Natasa Tozon 1, Ursa Lampreht Tratar 2, Katarina Znidar 3, Gregor Sersa 2, Justin Teissie 4,5, Maja Cemazar 2,3
1Clinic for Surgery and Small Animals, Veterinary Faculty, University of Ljubljana, 2Department of Experimental Oncology, Institute of Oncology Ljubljana, 3Faculty of Health Sciences, University of Primorska, 4IPBS (Institut de Pharmacologie et de Biologie Structurale), CNRS, 5IPBS (Institut de Pharmacologie et de Biologie Structurale), Université de Toulouse
Electrochemotherapy is the local treatment of solid tumors. The main mechanism is electroporation-mediated permeabilization of the tumor cells' membrane which enables increased internalization of cytostatics like bleomycin and cisplatin. Thus, antitumor effectiveness is potentiated at the site of the application of electric pulses to the tumors.
