Hadassah Academic College

2 ARTICLES PUBLISHED IN JoVE

Behavior

The Forced Swim Test as a Model of Depressive-like Behavior

Roni Yankelevitch-Yahav^1,2, Motty Franko², Avrham Huly², Ravid Doron^2,3,4

¹School of Psychological Sciences, Tel-Aviv University, ²School of Behavioral Sciences, Academic College of Tel Aviv-Yaffo, ³Department of Education and Psychology, The Open University of Israel, ⁴School of Health and Life Sciences, Hadassah Academic College

This protocol describes the forced swim test, which is used for the study of depressive-like behavior in rodents. This procedure involves placing an animal in a container filled with water that eventually will lead to the exhibition of immobility behavior, which is considered to reflect behavioral despair.

Behavior

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Or Burstein¹, Ravid Doron^1,2

¹School of Behavioral Science, The Academic College Tel-Aviv-Yaffo, ²Department of Education and Psychology, Open University

Here we present the unpredictable chronic mild stress protocol in mice. This protocol induces a long-term depressive-like phenotype and enables to assess the efficacy of putative antidepressants in reversing the behavioral and neuromolecular depressive-like deficits.