Westfälische Wilhelms-University Münster

2 ARTICLES PUBLISHED IN JoVE

Medicine

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

Michael T. Kuhlmann¹, Simon Cuhlmann^2,3, Irmgard Hoppe¹, Rob Krams³, Paul C. Evans², Gustav J. Strijkers⁴, Klaas Nicolay⁴, Sven Hermann¹, Michael Schäfers¹

¹European Institute for Molecular Imaging, Westfälische Wilhelms-University Münster, ²British Heart Foundation Cardiovascular Sciences Unit, Imperial College London , ³Department of Bioengineering, Imperial College London , ⁴Biomedical Engineering, Eindhoven University of Technology

The constricting cuff presented in this article is designed to induce atherosclerosis in the murine common carotid artery. Due to the conical shape of its inner lumen the implanted cuff generates well-defined regions of low, high and oscillatory shear stress triggering the development of atherosclerotic lesions of different inflammatory phenotypes.

JoVE Journal

Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using ¹⁸F-FDG PET

Alexander Grabner^*1, Dominik Kentrup^*1, Uta Schnöckel², Gert Gabriëls¹, Rita Schröter¹, Hermann Pavenstädt¹, Otmar Schober², Eberhard Schlatter¹, Michael Schäfers^*3, Stefan Reuter^*1

¹Department of Internal Medicine D, Experimental Nephrology, University of Münster, ²Department of Nuclear Medicine, University of Münster, ³European Institute for Molecular Imaging, University of Münster

We herein present a rat renal transplantation model to non-invasively assess acute allograft rejection using positron emission tomography with 18F-fluorodeoxyglucose.