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Montreal Heart Institute

3 ARTICLES PUBLISHED IN JoVE

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Bioengineering

Permeabilization of Adhered Cells Using an Inert Gas Jet
Scott Cooper 1, Paul Jonak 1, Guillaume Chouinard-Pelletier 1, Sylvain Coulombe 1, Elizabeth Jones 1, Richard L. Leask 1,2
1Chemical Engineering, McGill University, 2Montreal Heart Institute

This protocol describes a method for the temporary permeabilization of adherent cells using an inert gas jet. This technique facilitates the transfer of genetic material and biomolecules into adherent mammalian cells by the utilization of mechanical forces to disrupt the plasma membrane.

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Advancing the Assessment of Cardiac Injury and Function
Ienglam Lei 1, Pierre-Emmanuel Noly 2, Paul C. Tang 1
1Department of Cardiac Surgery, University of Michigan, Ann Arbor, 2Department of Cardiac Surgery, Montreal Heart Institute

Advancing the Assessment of Cardiac Injury and Function

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Medicine

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
Charles-Alexandre LeBlanc 1, Marie-Ève Higgins 1, Martin G. Sirois 1,2, Jean-François Tanguay 1,3, Jean-Claude Tardif 1,3, Roddy Hiram 1,3
1Montreal Heart Institute, 2Department of Pharmacology and Physiology, Université de Montréal, 3Department of Medicine, Faculty of Medicine, Université de Montréal

Right heart failure (RHF) is characterized by right-sided cardiac dilation and hypertrophy, leading to ventricular and atrial malfunction. Cardiopulmonary conditions associated with RHF are accompanied by an increased risk for cardiac arrhythmias. This article describes a standardized model of pulmonary artery banding-induced RHF associated with enhanced ventricular and atrial arrhythmogenesis.

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