Centre for Human Drug Research (CHDR)

2 ARTICLES PUBLISHED IN JoVE

Behavior

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Justin L. Hay¹, Pieter Okkerse¹, Guido van Amerongen¹, Geert Jan Groeneveld¹

Human pain models are valuable tools used to assess the analgesic potential of novel compounds and predict their clinical efficacy, especially when used in an integrated manner. Although implementation of these models is complex, with proper execution, the pain models described in this protocol can provide predictive and reliable results.

Education

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Ellen P. Hart¹, Ricardo Alvarez-Jimenez¹, Esther Davidse¹, Robert Jan Doll¹, Adam F. Cohen¹, Joop M.A. Van Gerven¹, Geert Jan Groeneveld¹

¹Centre for Human Drug Research (CHDR), Leiden

A validated computerized battery of neuropsychological and neurophysiological tests is used to study pharmacodynamic effects on the central nervous system of newly developed drugs in early phase development. To demonstrate the test battery, the acute effects of mecamylamine and the reversal of these effects by two agonist drugs are described.