A Multimodal Imaging Approach Based on Micro-CT and Fluorescence Molecular Tomography for Longitudinal Assessment of Bleomycin-Induced Lung Fibrosis in MiceFrancesca Ruscitti 1, Francesca Ravanetti 2, Gaetano Donofrio 2, Yanto Ridwan 3, Paula van Heijningen 3, Jeroen Essers 4, Gino Villetti 1, Antonio Cacchioli 2, Wim Vos 5, Franco Fabio Stellari 1
1Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 2Department of Veterinary Science, University of Parma, 3Department of Molecular Genetics, Erasmus MC, 4Department of Molecular Genetics, Vascular Surgery, Radiation Oncology, Erasmus MC, 5Fluidda NV
We describe a non-invasive multimodal imaging approach based on Micro-CT and fluorescence molecular tomography for longitudinal assessment of the mouse lung fibrosis model induced by double intratracheal instillation of bleomycin.
