University of Huddersfield
2 ARTICLES PUBLISHED IN JoVE
Cancer Research
Characterization of the Effects of Migrastatic Inhibitors on 3D Tumor Spheroid Invasion by High-resolution Confocal Microscopy
Jane Harmer 1, Nina Struve 2, Anke Brüning-Richardson 1
1School of Applied Sciences, University of Huddersfield, 2Laboratory of Radiotherapy and Experimental Radiation Oncology, Humbertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
The effects of migrastatic inhibitors on glioma cancer cell migration in three-dimensional (3D) invasion assays using a histone deacetylase (HDAC) inhibitor are characterized by high-resolution confocal microscopy.
Bioengineering
Agarose Fluid Gels Formed by Shear Processing During Gelation for Suspended 3D Bioprinting
Jessica J. Senior *1, Richard J. A. Moakes *2, Megan E. Cooke 3, Samuel R. Moxon 4, Alan M. Smith 1, Liam M. Grover 2
1Department of Pharmacy, University of Huddersfield, 2School of Chemical Engineering, University of Birmingham, 3Chemical and Biological Engineering, University of Colorado Boulder, 4School of Biological Sciences, University of Manchester
Shear processing during hydrogel formation results in the production of microgel suspensions that shear-thin but rapidly restructure following the removal of shear forces. Such materials have been used as a supporting matrix for bioprinting complex, cell-laden structures. Here, methods used to manufacture the supporting bed and compatible bioinks are described.
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