Tampere University and Tampere University Hospital
2 ARTICLES PUBLISHED IN JoVE
Cancer Research
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Maria Vähätupa *1, Toini Pemmari *1, Ilkka Junttila 1,2, Marko Pesu 1,2, Tero A.H. Järvinen 1
1Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 2Department of Clinical Microbiology, Fimlab Laboratories
Two-stage skin carcinogenesis is induced by two topically applied chemicals. A mutagen 7,12-dimethylbenz[a]anthracene) causes mutations in the epidermal cells and a continuous application of general growth stimulator 12-O-tetradecanoyl phorbol-13-acetate accelerates skin papilloma formation.
Medicine
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
Maria Vähätupa 1,2, Niina Jääskeläinen 2, Marc Cerrada-Gimenez 2, Rubina Thapa 2, Tero Järvinen 1, Giedrius Kalesnykas 2, Hannele Uusitalo-Järvinen 1,3
1Faculty of Medicine and Health Technology, Tampere University & Tampere University Hospital, 2Experimentica Ltd, 3Eye Centre, Tampere University Hospital
Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.
