Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic AnalysisIftekhar A. Showpnil 1,2, Kyle R. Miller 1, Cenny Taslim 1, Kathleen I. Pishas 1, Stephen L. Lessnick 1,3, Emily R. Theisen 1,4
1Center for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, 2Molecular, Cellular, and Developmental Biology Program, The Ohio State University, 3Division of Pediatric Hematology/Oncology/Blood & Marrow Transplant, The Ohio State University, 4Department of Pediatrics, The Ohio State University
Intrinsically disordered domains are important for oncogenic fusion transcription factor function. To therapeutically target these proteins, a more detailed understanding of the regulatory mechanisms employed by these domains is required. Here, we use transcriptomics to map important structural features of the intrinsically disordered EWS domain in Ewing sarcoma.
