Pingxiang People's Hospital of Southern Medical University

2 ARTICLES PUBLISHED IN JoVE

Biology

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Qiancheng Wang¹, Kaitong Chen¹, Hairuo Lin¹, Mingyuan He², Xiaoxia Huang¹, Hailin Zhu¹, Yulin Liao¹

¹Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, ²The Third Clinical Medical College, Guangzhou Medical University

Here, we provide a useful approach for studying the mechanism of right ventricular failure. A more convenient and efficient approach to pulmonary artery constriction is established using surgical instruments made inhouse. In addition, methods to evaluate the quality of this approach by echocardiography and catheterization are provided.

Medicine

Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy

Yi Lao¹, Cankun Zheng¹, Hailin Zhu^1,2, Hairuo Lin¹, Xiaoxia Huang¹, Yulin Liao¹

¹Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, ²Department of Geriatrics, Pingxiang People's Hospital of Southern Medical University

This protocol presents an improved method to obtain transient myocardial hypertrophy with absorbable suture, simulating left ventricular hypertrophy decrease after removing pressure overload. It could be valuable for the studies on myocardial hypertrophic preconditioning.