Shandong Co-Innovation Center of Classic TCM Formula, Shandong Provincial Education Department

1 ARTICLES PUBLISHED IN JoVE

Medicine

A New Model of Heart Failure Post-Myocardial Infarction in the Rat

Honglei Li^1,2, Jiansheng Huang³, Caihong Liu¹, Zhentao Zhang³, Kuiquan Song², Ke Ma¹, Connor W. Dennewitz³, Shijun Wang^1,4

¹College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, ²Department of Intensive Care Unit, Jinan Municipal Hospital of Traditional Chinese Medicine, ³Department of Medicine, Vanderbilt University Medical Center, ⁴Shandong Co-Innovation Center of Classic TCM Formula, Shandong Provincial Education Department

We successfully developed a reliable and reproducible model of heart failure post-myocardial infarction in the rat without ventilation or exteriorization of the heart. This simplifies the procedure and benefits the further studies about the potential mechanisms behind the heart failure.