The First Clinical College of Dalian Medical University

1 ARTICLES PUBLISHED IN JoVE

Medicine

Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice

Ruoxi Liao¹, Mingyuan He², Donghong Hu², Chengzheng Gong¹, Huiying Du¹, Hairuo Lin², Huijun Sun³

¹The First Clinical College of Dalian Medical University, ²Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, ³College of Pharmacy, Dalian Medical University

There are several differences between the right and left ventricles. However, the pathophysiology of right ventricular infarction (RVI) has not been clarified. In the present protocol, a reproducible method for RVI mouse model generation is introduced, which may provide a means to explain the mechanism of RVI.