Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension ModelLingfeng Qin 1, Bo Jiang 2, Krisztina Zsebo 3, Henricus J. Duckers 3, Michael Simons 4,5, Pei-Yu Chen 4
1Department of Surgery, Yale University School of Medicine, 2Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 5Department of Cell Biology, Yale University School of Medicine
This protocol provides a step-by-step procedure for executing multiple intravenous bolus dose administration and invasive hemodynamic monitoring in mice. Investigators can use this protocol for future therapeutic compound screening for pulmonary artery hypertension.
