Sunnybrook Health Sciences Centre

3 ARTICLES PUBLISHED IN JoVE

Medicine

An Investigation of the Effects of Sports-related Concussion in Youth Using Functional Magnetic Resonance Imaging and the Head Impact Telemetry System

Michelle Keightley^1,2,3,4,5, Stephanie Green¹, Nick Reed¹, Sabrina Agnihotri¹, Amy Wilkinson³, Nancy Lobaugh^6,7

¹Graduate Department of Rehabilitation Science, University of Toronto, ²Occupational Science and Occupational Therapy, University of Toronto, ³Department of Psychology, University of Toronto, ⁴Bloorview Kids Rehab, ⁵Toronto Rehab, ⁶Cognitive Neurology, Sunnybrook Health Sciences Centre, ⁷Faculty of Medicine, University of Toronto

This article provides an overview of a multi-modal approach to mild traumatic brain injury diagnosis and recovery in youth. This approach combines neuropsychological testing with functional magnetic resonance imaging and the Head Impact Telemetry System to monitor the relationship between head impacts and brain activity during cognitive testing.

Medicine

Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly

Joel Ramirez¹, Christopher J.M. Scott¹, Alicia A. McNeely¹, Courtney Berezuk¹, Fuqiang Gao¹, Gregory M. Szilagyi^1,2, Sandra E. Black^1,2

¹LC Campbell Cognitive Neurology Research Unit, Heart & Stroke Foundation Canadian Partnership for Stroke Recovery, Brain Sciences Research Program, Sunnybrook Health Sciences Centre, ²Department of Medicine (Neurology), Institute of Medical Science, University of Toronto

Lesion Explorer (LE) is a semi-automatic, image-processing pipeline developed to obtain regional brain tissue and subcortical hyperintensity lesion volumetrics from structural MRI of Alzheimer's disease and normal elderly. To ensure a high level of accuracy and reliability, the following is a video-guided, standardized protocol for LE's manual procedures.

Medicine

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Ying Meng¹, Yuexi Huang², Benjamin Solomon², Kullervo Hynynen², Nadia Scantlebury¹, Michael L. Schwartz¹, Nir Lipsman¹

¹Division of Neurosurgery, Sunnybrook Health Sciences Centre, ²Sunnybrook Research Institute, Sunnybrook Health Sciences Centre

High-intensity MRI guided focused ultrasound is an emerging noninvasive technique to precisely ablate brain tissue. It has been shown to be safe and effective in treating medically-refractory essential tremor. This article describes the protocol for thalamotomy from patient selection to equipment setup to post-treatment follow-up.