preparation for roller microneedling therapy in the treatment of melasma

用氨甲环酸和微针疗法加强黄褐斑治疗

Melasma, also known as chloasma, is a chronic and acquired facial hyperpigmentation skin condition. Clinically, it presents as symmetrical, light to dark brown patches with unclear borders, distributed on the cheeks, forehead, and jawline. The incidence rate among Asian women of childbearing age can be as high as 30%1. The disease is easily diagnosed but difficult to cure. The pathogenesis of melasma is not yet fully understood, but three main factors contribute to its development: genetic susceptibility, exposure to sunlight, and hormonal changes. Increased melanin synthesis, vascular proliferation at the site of skin lesions, inflammatory reactions, and impaired skin barrier function all play a role in the occurrence of melasma2.
Currently, treatment options for melasma include laser therapy and medications, among which, transdermal administration is a widely used method. However, the main challenge lies in the barrier function of the stratum corneum, which hinders drug penetration. Microneedle therapy creates multiple micro-channels in the skin within a short period, disrupting the stratum corneum, inducing collagen production, and increasing skin permeability. This approach holds promise in allowing drugs to diffuse into the skin and then rapidly reseal, thus avoiding the introduction of toxic or irritating substances3.
Commonly used microneedle tools include the electronic water light injection microneedle, roller microneedle, electrically assisted nanocrystalline microneedle, plum blossom microneedle, and single needle microneedle4. The roller microneedle is characterized by less trauma, good curative effect, convenient operation, and can be combined with some other drugs to treat melasma. It has a good therapeutic prospect for melasma and is worth more promotion and use in clinical practice. This article introduces the operation and precautions of roller microneedles combined with tranexamic acid in the treatment of melasma and demonstrates the efficacy of roller microneedle combined with tranexamic acid in the treatment of melasma through clinical cases.

作者聚焦： 黄褐斑的非手术治疗 – 氨甲环酸微针

滚筒微针联合氨甲环酸溶液治疗黄褐斑

Our research focus on non-surgery therapy for pigmentated disease. We tested the efficacy of roller microneedling combined with tranexamic acid solution in treating melasma. We will investigate the effectiveness and the max easiness of using a combination of roller microneedles and tranexamic acid solution for treating melasma.

滚筒微针疗法治疗黄褐斑的准备工作

首先，准备一个安静且光线充足的治疗室，并在手术前用紫外线消毒 30 分钟。指导患者在进入治疗室之前戴上鞋套和帽子。如果治疗区域被化妆品覆盖，请使用卸妆液彻底卸妆。对于不化妆的人，用温和的清洁产品清洁治疗区域。在开始治疗之前和第三次治疗后，使用多光谱皮肤镜从三个不同角度捕捉患者前部、左侧和右侧的图像。记录调查结果，包括浅紫外线、深斑点和褐斑点的强度。然后将 5% 利多卡因乳膏均匀地涂抹在治疗区域。用保鲜膜包裹该区域，以增强麻木效果 40 至 60 分钟。接下来，用注射器抽出 5 毫升 5% 氨甲环酸溶液以备后用。要制备 0.5 毫米滚筒微针，请将其浸入 0.1% 苯扎溴铵溶液中 20 分钟以进行消毒。用生理盐水对微针进行三次冲洗，以消除消毒剂的任何痕迹。在充分的麻醉剂应用后，撕下保鲜膜。用刮刀去除麻醉霜，然后用蘸有 0.9% 盐水溶液的纱布清洁任何残留物。在治疗面部区域时，用消毒毛巾将头发向后固定，使治疗区域易于触及。用浸有0.1%苯扎溴铵溶液的棉球从面部顶部到发际线，然后到下颌边缘和下巴对面部皮肤进行消毒。

preparation-for-roller-microneedling-therapy-treatment

Research

JoVE Journal

Medicine

Preparation for Roller Microneedling Therapy in the Treatment of Melasma

52 次观看.  Chongqing Hospital of Traditional Chinese Medicine. 首先，准备一个安静且光线充足的治疗室，并在手术前用紫外线消毒 30 分钟。指导患者在进入治疗室之前戴上鞋套和帽子。如果治疗区域被化妆品覆盖，请使用卸妆液彻底卸妆。对于不化妆的人，用温和的清洁产品清洁治疗区域。在开始治疗之前和第三次治疗后，使用多光谱皮肤镜从三个不同角度捕捉患者前部、左侧和右侧的图像。记录调查结果，包括浅紫外线、深斑...

视频: 滚筒微针疗法治疗黄褐斑的准备工作

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective management. The precise underlying causes of melasma remain elusive, and the current therapeutic approaches predominantly encompass pharmaceutical and laser interventions, with limited efficacy. Transdermal administration stands as a prevalent treatment method for melasma, often facilitated by the application of microneedles. Among these, tranexamic acid emerges as a frequently employed therapeutic agent. A subset of microneedles, known as roller microneedles, plays a significant role in this approach by delicately puncturing the epidermis with multiple fine needles, synergizing with drug delivery. This methodology not only enhances drug absorption but also augments treatment efficacy while minimizing tissue trauma. These attributes forecast promising avenues for the treatment of melasma. This article primarily introduces the combination of roller microneedle and tranexamic acid solution in the treatment of melasma and demonstrates the efficacy of roller microneedle and tranexamic acid solution in the treatment of melasma through clinical cases.

This article presents a protocol to conduct the treatment of melasma by using roller microneedles in combination with tranexamic acid solution and evaluate the efficacy.

Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective ...