roller microneedle procedure for treating melasma and efficacy evaluation of the procedure

用氨甲环酸和微针疗法加强黄褐斑治疗

Melasma, also known as chloasma, is a chronic and acquired facial hyperpigmentation skin condition. Clinically, it presents as symmetrical, light to dark brown patches with unclear borders, distributed on the cheeks, forehead, and jawline. The incidence rate among Asian women of childbearing age can be as high as 30%1. The disease is easily diagnosed but difficult to cure. The pathogenesis of melasma is not yet fully understood, but three main factors contribute to its development: genetic susceptibility, exposure to sunlight, and hormonal changes. Increased melanin synthesis, vascular proliferation at the site of skin lesions, inflammatory reactions, and impaired skin barrier function all play a role in the occurrence of melasma2.
Currently, treatment options for melasma include laser therapy and medications, among which, transdermal administration is a widely used method. However, the main challenge lies in the barrier function of the stratum corneum, which hinders drug penetration. Microneedle therapy creates multiple micro-channels in the skin within a short period, disrupting the stratum corneum, inducing collagen production, and increasing skin permeability. This approach holds promise in allowing drugs to diffuse into the skin and then rapidly reseal, thus avoiding the introduction of toxic or irritating substances3.
Commonly used microneedle tools include the electronic water light injection microneedle, roller microneedle, electrically assisted nanocrystalline microneedle, plum blossom microneedle, and single needle microneedle4. The roller microneedle is characterized by less trauma, good curative effect, convenient operation, and can be combined with some other drugs to treat melasma. It has a good therapeutic prospect for melasma and is worth more promotion and use in clinical practice. This article introduces the operation and precautions of roller microneedles combined with tranexamic acid in the treatment of melasma and demonstrates the efficacy of roller microneedle combined with tranexamic acid in the treatment of melasma through clinical cases.

作者聚焦： 黄褐斑的非手术治疗 – 氨甲环酸微针

滚筒微针联合氨甲环酸溶液治疗黄褐斑

Our research focus on non-surgery therapy for pigmentated disease. We tested the efficacy of roller microneedling combined with tranexamic acid solution in treating melasma. We will investigate the effectiveness and the max easiness of using a combination of roller microneedles and tranexamic acid solution for treating melasma.

滚筒微针治疗黄褐斑的手术及疗效评价

在开始该程序之前，治疗师应洗手，戴上帽子，口罩和无菌手套，以确保适当的卫生。指导患者闭上眼睛。使用注射器将氨甲环酸溶液施加到皮肤上，并用手均匀分布。用生理盐水清洁滚筒微针，并在治疗区域以水平、垂直和对角线模式短距离滚动微针。处理不同的区域，将溶液的应用与滚动动作相结合，以促进吸收。重复该过程三到五次，同时在不拖动微针的情况下施加均匀的压力，确保皮肤潮红但不会出血。使用多光谱皮肤镜在每次疗程前后评估治疗效果。通过监测紫外线浅点和深点的减少，以及表明黄褐斑闪电的褐色斑点的减少，评估治疗效果。进行统计分析，比较治疗前后紫外线、浅层、深层斑点和褐色斑点的变化。

roller-microneedle-procedure-for-treating-melasma-efficacy-evaluation

Research

JoVE Journal

Medicine

Roller Microneedle Procedure for Treating Melasma and Efficacy Evaluation of the Procedure

39 次观看.  Chongqing Hospital of Traditional Chinese Medicine. 在开始该程序之前，治疗师应洗手，戴上帽子，口罩和无菌手套，以确保适当的卫生。指导患者闭上眼睛。使用注射器将氨甲环酸溶液施加到皮肤上，并用手均匀分布。用生理盐水清洁滚筒微针，并在治疗区域以水平、垂直和对角线模式短距离滚动微针。处理不同的区域，将溶液的应用与滚动动作相结合，以促进吸收。重复该过程三到五次，同时在不拖动微针的情况下?...

视频: 滚筒微针治疗黄褐斑的手术及疗效评价

Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective management. The precise underlying causes of melasma remain elusive, and the current therapeutic approaches predominantly encompass pharmaceutical and laser interventions, with limited efficacy. Transdermal administration stands as a prevalent treatment method for melasma, often facilitated by the application of microneedles. Among these, tranexamic acid emerges as a frequently employed therapeutic agent. A subset of microneedles, known as roller microneedles, plays a significant role in this approach by delicately puncturing the epidermis with multiple fine needles, synergizing with drug delivery. This methodology not only enhances drug absorption but also augments treatment efficacy while minimizing tissue trauma. These attributes forecast promising avenues for the treatment of melasma. This article primarily introduces the combination of roller microneedle and tranexamic acid solution in the treatment of melasma and demonstrates the efficacy of roller microneedle and tranexamic acid solution in the treatment of melasma through clinical cases.

This article presents a protocol to conduct the treatment of melasma by using roller microneedles in combination with tranexamic acid solution and evaluate the efficacy.

Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective ...