Alexei Protopopov

A new approach to genome mapping and sequencing: slalom libraries.

hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein.

The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells.

Human cell lines engineered for tetracycline-regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21.

NotI flanking sequences: a tool for gene discovery and verification of the human genome.

NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes.

An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies.

Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas.

Restriction site tagged (RST) microarrays: a novel technique to study the species composition of complex microbial systems.

mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.

High-resolution global profiling of genomic alterations with long oligonucleotide microarray.

High-resolution genomic profiles of human lung cancer.

Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential.

hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men.

Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment.

Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations.

High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients.

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors.

The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis.

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

A comparison of DNA copy number profiling platforms.

Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.

Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (aCGH).

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.

Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.

Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1.

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.

Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.

High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer.

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer.

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis.

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.

Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia.

Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor.

Altered antisense-to-sense transcript ratios in breast cancer.

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.

Telomere dysfunction induces metabolic and mitochondrial compromise.

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia.

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.

Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma.

DNA breaks and chromosome pulverization from errors in mitosis.

Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.

Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases.

Melanoma genome sequencing reveals frequent PREX2 mutations.

Spectrum of somatic mitochondrial mutations in five cancers.

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment.

TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity.

Diverse mechanisms of somatic structural variations in human cancer genomes.

ZNF365 Promotes Stability of Fragile * Sites and Telomeres.

Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy.

Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer.

Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer.

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing.

Characterization of HPV and host genome interactions in primary head and neck cancers.

Telomere dysfunction suppresses multiple endocrine neoplasia in mice.

Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia.

Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma.