Alexei Protopopov

Institute of Applied Cancer Science, UT MD Anderson Cancer Center

Affiliated withUT MD Anderson Cancer Center

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2015

Other Publications

Article	Year
A new approach to genome mapping and sequencing: slalom libraries. Nucleic acids research\| PubMed ID: 11788732	2002
hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein. Gene\| PubMed ID: 11867227	2002
The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells. Cancer research\| PubMed ID: 12067994	2002
Human cell lines engineered for tetracycline-regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region, 3p21. The journal of gene medicine\| PubMed ID: 12124982	2002
NotI flanking sequences: a tool for gene discovery and verification of the human genome. Nucleic acids research\| PubMed ID: 12136098	2002
NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12149436	2002
An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. Cancer research\| PubMed ID: 12543795	2003
Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas. Oncogene\| PubMed ID: 12771950	2003
Restriction site tagged (RST) microarrays: a novel technique to study the species composition of complex microbial systems. Nucleic acids research\| PubMed ID: 12907747	2003
mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes & development\| PubMed ID: 14522945	2003
High-resolution global profiling of genomic alterations with long oligonucleotide microarray. Cancer research\| PubMed ID: 15256441	2004
High-resolution genomic profiles of human lung cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15983384	2005
Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential. Molecular cancer\| PubMed ID: 16022731	2005
hUNC-93B1, a novel gene mainly expressed in the heart, is related to left ventricular diastolic function, heart failure morbidity and mortality in elderly men. European journal of heart failure\| PubMed ID: 16111919	2005
Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment. Cancer research\| PubMed ID: 16288000	2005
Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer cell\| PubMed ID: 16473278	2006
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer cell\| PubMed ID: 16616336	2006
Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16672372	2006
The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer cell\| PubMed ID: 17418411	2007
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature\| PubMed ID: 17515920	2007
A comparison of DNA copy number profiling platforms. Cancer research\| PubMed ID: 17968032	2007
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer research\| PubMed ID: 18006816	2007
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis\| PubMed ID: 18283039	2008
Full complexity genomic hybridization on 60-mer oligonucleotide microarrays for array comparative genomic hybridization (aCGH). Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18370097	2008
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer cell\| PubMed ID: 18394558	2008
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18669646	2008
Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1. The Journal of experimental medicine\| PubMed ID: 18981238	2008
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19050074	2008
Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications. Blood\| PubMed ID: 19270264	2009
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood\| PubMed ID: 19458356	2009
High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancer. PloS one\| PubMed ID: 19478941	2009
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature\| PubMed ID: 19553991	2009
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell stem cell\| PubMed ID: 19896444	2009
Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood\| PubMed ID: 20124220	2010
Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 20644084	2010
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes & development\| PubMed ID: 20837658	2010
Altered antisense-to-sense transcript ratios in breast cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21098291	2012
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature\| PubMed ID: 21113150	2011
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature\| PubMed ID: 21307849	2011
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood\| PubMed ID: 21878675	2011
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. Cancer discovery\| PubMed ID: 21984975	2011
Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma. Haematologica\| PubMed ID: 22102711	2012
DNA breaks and chromosome pulverization from errors in mitosis. Nature\| PubMed ID: 22258507	2012
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell\| PubMed ID: 22341440	2012
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell\| PubMed ID: 22341455	2012
Melanoma genome sequencing reveals frequent PREX2 mutations. Nature\| PubMed ID: 22622578	2012
Spectrum of somatic mitochondrial mutations in five cancers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22891333	2012
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nature cell biology\| PubMed ID: 23624405	2013
TRIM13 (RFP2) downregulation decreases tumour cell growth in multiple myeloma through inhibition of NF Kappa B pathway and proteasome activity. British journal of haematology\| PubMed ID: 23647456	2013
Diverse mechanisms of somatic structural variations in human cancer genomes. Cell\| PubMed ID: 23663786	2013
ZNF365 Promotes Stability of Fragile * Sites and Telomeres. Cancer discovery\| PubMed ID: 23776040	2013
Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nature cell biology\| PubMed ID: 23831727	2013
Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. The Journal of biological chemistry\| PubMed ID: 24398677	2014
Recurrent PTPRB and PLCG1 mutations in angiosarcoma. Nature genetics\| PubMed ID: 24633157	2014
Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell\| PubMed ID: 24954535	2014
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science (New York, N.Y.)\| PubMed ID: 25301631	2014
Characterization of HPV and host genome interactions in primary head and neck cancers. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25313082	2014
Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes & cancer\| PubMed ID: 25352948	2014
Identification of a novel fusion gene, IRF2BP2-RARA, in acute promyelocytic leukemia. Journal of the National Comprehensive Cancer Network : JNCCN\| PubMed ID: 25583766	2015
Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma. The Journal of clinical investigation\| PubMed ID: 25705882	2015