Sergei Sukharev

Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes.

A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension.

On the conformation of the COOH-terminal domain of the large mechanosensitive channel MscL.

Mechanosensitive channels: multiplicity of families and gating paradigms.

Gating of the large mechanosensitive channel in situ: estimation of the spatial scale of the transition from channel population responses.

Water dynamics and dewetting transitions in the small mechanosensitive channel MscS.

Mechanosensitive channels: what can we learn from 'simple' model systems?

The "dashpot" mechanism of stretch-dependent gating in MscS.

Gain-of-function mutations reveal expanded intermediate states and a sequential action of two gates in MscL.

Explicit channel conductance: can it be computed?

Capping transmembrane helices of MscL with aromatic residues changes channel response to membrane stretch.

2,2,2-Trifluoroethanol changes the transition kinetics and subunit interactions in the small bacterial mechanosensitive channel MscS.

Characterization of the resting MscS: modeling and analysis of the closed bacterial mechanosensitive channel of small conductance.

Straightening and sequential buckling of the pore-lining helices define the gating cycle of MscS.

Mechanosensitive channel MscS in the open state: modeling of the transition, explicit simulations, and experimental measurements of conductance.

The membrane lateral pressure-perturbing capacity of parabens and their effects on the mechanosensitive channel directly correlate with hydrophobicity.

State-stabilizing Interactions in Bacterial Mechanosensitive Channel Gating and Adaptation.

The tension-transmitting 'clutch' in the mechanosensitive channel MscS.

Gadolinium ions block mechanosensitive channels by altering the packing and lateral pressure of anionic lipids.

Adaptive behavior of bacterial mechanosensitive channels is coupled to membrane mechanics.

Mechanosensitive channels in microbes.

Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts.

Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models.

Structural models of TREK channels and their gating mechanism.

Adaptive MscS gating in the osmotic permeability response in E. coli: the question of time.

The pathway and spatial scale for MscS inactivation.

Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules.

Molecular force transduction by ion channels: diversity and unifying principles.

The mechanoelectrical response of the cytoplasmic membrane of Vibrio cholerae.

The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells.

The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding.

Properties of diphytanoyl phospholipids at the air-water interface.

Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase.

Membrane Affinity of Platensimycin and Its Dialkylamine Analogs.

Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations.

Activation of bacterial channel MscL in mechanically stimulated droplet interface bilayers.