Carl Atkinson

Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.

Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma.

Complement-dependent P-selectin expression and injury following ischemic stroke.

A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice.

Upregulated expression of complement inhibitory proteins on bladder cancer cells and anti-MUC1 antibody immune selection.

Modulation of protective T cell immunity by complement inhibitor expression on tumor cells.

A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury.

A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice.

Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury.

A role for complement in the enhanced susceptibility of steatotic livers to ischemia and reperfusion injury.

Cigarette smoke extract stimulates interleukin-8 production in human airway epithelium and is attenuated by superoxide dismutase in vitro.

Complement-dependent inflammation and injury in a murine model of brain dead donor hearts.

Alterations in gene expression of complement components in chronic rhinosinusitis.

Ketamine-xylazine-acepromazine compared with isoflurane for anesthesia during liver transplantation in rodents.

Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10.

Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damage.

The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury.

Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.

Complement inhibition alleviates paraquat-induced acute lung injury.

Toll-like receptor 4 knockout mice are protected from endothelial overactivation in the absence of Kupffer cells after total hepatic ischemia/reperfusion.

Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice.

Human sinonasal epithelial cells direct dendritic function and T-cell T helper 1/T helper 2 skewing following Aspergillus exposure.

Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis.

A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer.

Complement-dependent injury and protection in a murine model of acute dextran sulfate sodium-induced colitis.

Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma.

The alternative complement pathway propagates inflammation and injury in murine ischemic stroke.

A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor.

Donor brain death exacerbates complement-dependent ischemia/reperfusion injury in transplanted hearts.

Targeting complement component 5a promotes vascular integrity and limits airway remodeling.

Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury.

Z α1-antitrypsin confers a proinflammatory phenotype that contributes to chronic obstructive pulmonary disease.

Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis.

Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation.

Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy.

Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury.

Immunosuppressive nano-therapeutic micelles downregulate endothelial cell inflammation and immunogenicity.

A simplified cuff technique for abdominal aortic transplantation in mice.

Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement.

A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury.

New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities.

Targeted Complement Inhibition Protects Vascularized Composite Allografts From Acute Graft Injury and Prolongs Graft Survival When Combined With Subtherapeutic Cyclosporine A Therapy.

Memory CD4T cells are suppressed by CD8regulatory T cells in vitro and in vivo.

Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury.

Th17 cells are refractory to senescence and retain robust antitumor activity after long-term ex vivo expansion.

Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells.

Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement.

Serum Proteins Associated with Emphysema Progression in Severe Alpha-1 Antitrypsin Deficiency.

Natural immunoglobulin M initiates an inflammatory response important for both hepatic ischemia reperfusion injury and regeneration in mice.

Dietary vitamin D3 deficiency exacerbates sinonasal inflammation and alters local 25(OH)D3 metabolism.

Nanotechnological Approaches to Immunosuppression and Tolerance Induction.

The role of regulatory T cells in the regulation of upper airway inflammation.

Donor Pre-treatment with nebulized complement C3a Receptor antagonist mitigates brain-death induced immunological injury post-lung transplant.

Impact of Mitochondrial Permeability on Endothelial Cell Immunogenicity in Transplantation.