Leicester Cancer Research Center
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MEK kinase activity is not necessary for Raf-1 function.
The EMBO journal Apr, 2001 | Pubmed ID: 11296227
ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf.
Oncogene Jan, 2002 | Pubmed ID: 11821947
MEKK1 plays a critical role in activating the transcription factor C/EBP-beta-dependent gene expression in response to IFN-gamma.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2002 | Pubmed ID: 12048245
Expression of kinase suppressor of Ras in the normal adult and embryonic mouse.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research Jul, 2002 | Pubmed ID: 12133899
cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells.
The Journal of biological chemistry Dec, 2002 | Pubmed ID: 12364324
Analysis of the role of the SA gene in blood pressure regulation by gene targeting.
Hypertension (Dallas, Tex. : 1979) Jun, 2003 | Pubmed ID: 12707288
Raf proteins and cancer: B-Raf is identified as a mutational target.
Biochimica et biophysica acta Jun, 2003 | Pubmed ID: 12781369
B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts.
Molecular and cellular biology Jul, 2004 | Pubmed ID: 15199148
A critical function for B-Raf at multiple stages of myelopoiesis.
Blood Aug, 2005 | Pubmed ID: 15784729
A-Raf and Raf-1 work together to influence transient ERK phosphorylation and Gl/S cell cycle progression.
Oncogene Aug, 2005 | Pubmed ID: 15856007
Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts.
Cancer research Dec, 2005 | Pubmed ID: 16357158
Mouse models for BRAF-induced cancers.
Biochemical Society transactions Nov, 2007 | Pubmed ID: 17956344
Lineage tracing of cardiac explant derived cells.
PloS one Apr, 2008 | Pubmed ID: 18414652
Cdx2 initiates histodifferentiation of the midgut endoderm.
FEBS letters Jul, 2008 | Pubmed ID: 18577384
CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.
Molecular cell Sep, 2008 | Pubmed ID: 18922468
Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms.
The FEBS journal Mar, 2009 | Pubmed ID: 19220457
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Cell Jan, 2010 | Pubmed ID: 20141835
Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.
European journal of cell biology Sep, 2010 | Pubmed ID: 20605055
V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4a.
EMBO molecular medicine Nov, 2010 | Pubmed ID: 20941790
BRAF inactivation drives aneuploidy by deregulating CRAF.
Cancer research Nov, 2010 | Pubmed ID: 20978199
Endothelial cell talin1 is essential for embryonic angiogenesis.
Developmental biology Jan, 2011 | Pubmed ID: 21081121
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2011 | Pubmed ID: 21220306
Mechanisms of aneuploidy induction by RAS and RAF oncogenes.
American journal of cancer research , 2011 | Pubmed ID: 22016838
Cdx2 determines the fate of postnatal intestinal endoderm.
Development (Cambridge, England) Feb, 2012 | Pubmed ID: 22190642
Regulation of MEK/ERK pathway output by subcellular localization of B-Raf.
Biochemical Society transactions Feb, 2012 | Pubmed ID: 22260667
The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway.
Genes & development Sep, 2012 | Pubmed ID: 22892241
Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile.
Biochemical and biophysical research communications Sep, 2012 | Pubmed ID: 22925892
A new mode of RAF autoregulation: a further complication in the inhibitor paradox.
Cancer cell May, 2013 | Pubmed ID: 23680140
A complex secretory program orchestrated by the inflammasome controls paracrine senescence.
Nature cell biology Aug, 2013 | Pubmed ID: 23770676
Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720.
Molecular cancer research : MCR Dec, 2013 | Pubmed ID: 24152792
Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels.
Molecular pharmacology Aug, 2014 | Pubmed ID: 24830940
Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
PLoS biology Jul, 2014 | Pubmed ID: 25003521
KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1.
Laboratory investigation; a journal of technical methods and pathology Jul, 2015 | Pubmed ID: 26146959
MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients.
Oncotarget Sep, 2015 | Pubmed ID: 26172302
The cholesterol-binding protein NPC2 restrains recruitment of stromal macrophage-lineage cells to early-stage lung tumours.
EMBO molecular medicine Sep, 2015 | Pubmed ID: 26183450
Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor.
Cellular signalling Jun, 2016 | Pubmed ID: 26898828
Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine.
PloS one , 2016 | Pubmed ID: 27284979
Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma.
Nature communications Aug, 2016 | Pubmed ID: 27558455
Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.
The Journal of biological chemistry 02, 2017 | Pubmed ID: 28073913
Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy.
Cancer research 04, 2017 | Pubmed ID: 28202521
Attenuation Limits Progression of -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAF Inhibitor PLX4720.
Cancer research 04, 2017 | Pubmed ID: 28242615
KRAS expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment.
Blood 07, 2017 | Pubmed ID: 28550040
Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer.
Oncotarget Oct, 2017 | Pubmed ID: 29152076
Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK.
Heliyon Dec, 2018 | Pubmed ID: 30603699
Early detection of pre-malignant lesions in a KRAS-driven mouse lung cancer model by monitoring circulating free DNA.
Disease models & mechanisms 02, 2019 | Pubmed ID: 30760495
Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer.
Gynecologic oncology 01, 2020 | Pubmed ID: 31767187
Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery.
British journal of cancer 03, 2020 | Pubmed ID: 31894140
DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.
iScience Feb, 2020 | Pubmed ID: 32058953
Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma.
JNCI cancer spectrum Apr, 2020 | Pubmed ID: 32190817
Exploration of Matrix Effects in Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Cisplatin-Treated Tumors.
Analytical chemistry 07, 2020 | Pubmed ID: 32545955
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.
Cell reports 06, 2020 | Pubmed ID: 32579928
Development of a patient-derived explant model for prediction of drug responses in endometrial cancer.
Gynecologic oncology Feb, 2021 | Pubmed ID: 33309417
Evaluating and comparing immunostaining and computational methods for spatial profiling of drug response in patient-derived explants.
Laboratory investigation; a journal of technical methods and pathology Dec, 2020 | Pubmed ID: 33318618
Ras/MAPK Dysregulation in Development Causes a Skeletal Myopathy in an Activating Braf Mouse Model for Cardio-facio-cutaneous Syndrome.
Developmental dynamics : an official publication of the American Association of Anatomists Feb, 2021 | Pubmed ID: 33522658
Digoxin treatment reactivates in vivo radioactive iodide uptake and correlates with favorable clinical outcome in non-medullary thyroid cancer.
Cellular oncology (Dordrecht) Feb, 2021 | Pubmed ID: 33534128
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