Haoxing Xu

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.

Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis.

Mucolipins: Intracellular TRPML1-3 channels.

TRP channels of intracellular membranes.

Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders.

TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.

PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.

Pairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes.

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.

Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts.

Phosphoinositide isoforms determine compartment-specific ion channel activity.

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes.

A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis.

Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.

Lysosomal exocytosis and lipid storage disorders.

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells.

TRPML1: an ion channel in the lysosome.

Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.

The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.

Lysosomal physiology.

Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB.

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.

Organellar channels and transporters.

A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion.

Calcium signaling in membrane repair.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes.

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.

Lysosome calcium in ROS regulation of autophagy.

PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment.

A painful TR(i)P to lysosomes.

Visualization of Phosphatidylinositol 3,5-Bisphosphate Dynamics by a Tandem ML1N-Based Fluorescent Protein Probe in Arabidopsis.

A voltage-dependent K channel in the lysosome is required for refilling lysosomal Ca stores.

Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca Efflux Channel in the Tubulovesicle.

Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells.

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.

Release and uptake mechanisms of vesicular Ca stores.