Mansoor Amiji

pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH Financial support was provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT Biotechnology Process Engineering Center), the NIH (GM26698), and the Department of the Army (Cooperative Agreement DAMD 17-99-2-9-001 to the Center for Innovative Minimally Invasive Therapy). D.M.L. wishes to thank the NIH for a Postdoctoral Fellowship (NRSA Fellowship No. 1 F32 GM20227-01). Scanning electron microscopy and confocal microscopy images were acquired by William Fowle at the Northeastern University Center for Electron Microscopy. Dr. David Putnam, David Ting, and Tommy Thomas are thanked for helpful discussions.

Stomach-specific anti-H. pylori therapy. I: Preparation and characterization of tetracyline-loaded chitosan microspheres.

Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations.

Intratumoral administration of paclitaxel in an in situ gelling poloxamer 407 formulation.

Long-circulating poly(ethylene glycol)-modified gelatin nanoparticles for intracellular delivery.

Biodegradable poly(epsilon -caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen.

Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery.

Chitosan-based gastrointestinal delivery systems.

Cellular uptake and concentrations of tamoxifen upon administration in poly(epsilon-caprolactone) nanoparticles.

Stomach-specific anti-H. pylori therapy. II. Gastric residence studies of tetracycline-loaded chitosan microspheres in gerbils.

Enzyme immobilization in novel alginate-chitosan core-shell microcapsules.

Stomach-specific anti-H. pylori therapy; part III: effect of chitosan microspheres crosslinking on the gastric residence and local tetracycline concentrations in fasted gerbils.

Poly-N-acetyl glucosamine-mediated red blood cell interactions.

Biodistribution and targeting potential of poly(ethylene glycol)-modified gelatin nanoparticles in subcutaneous murine tumor model.

Cellular interactions and in vitro DNA transfection studies with poly(ethylene glycol)-modified gelatin nanoparticles.

Poly(ethylene oxide)-modified poly(epsilon-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer.

Tumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studies.

Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations.

An approach to heterobifunctional poly(ethyleneglycol) bioconjugates.

Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies.

Preparation and evaluation of thiol-modified gelatin nanoparticles for intracellular DNA delivery in response to glutathione.

Long-circulating polymeric nanovectors for tumor-selective gene delivery.

Formulation optimization for the nanoparticles-in-microsphere hybrid oral delivery system using factorial design.

Surface functionalization of gold nanoparticles using hetero-bifunctional poly(ethylene glycol) spacer for intracellular tracking and delivery.

Multi-functional polymeric nanoparticles for tumour-targeted drug delivery.

A review of nanocarrier-based CNS delivery systems.

Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model.

Nanoparticulate drug carriers for delivery of HIV/AIDS therapy to viral reservoir sites.

Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS.

Improved oral delivery of paclitaxel following administration in nanoemulsion formulations.

Biodistribution and pharmacokinetic analysis of long-circulating thiolated gelatin nanoparticles following systemic administration in breast cancer-bearing mice.

Role of nanotechnology in HIV/AIDS treatment: potential to overcome the viral reservoir challenge.

Formulation and physiological factors influencing CNS delivery upon intranasal administration.

An overview of condensing and noncondensing polymeric systems for gene delivery.

Poly(ethylene glycol)-modified thiolated gelatin nanoparticles for glutathione-responsive intracellular DNA delivery.

Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery.

Gastrointestinal distribution and in vivo gene transfection studies with nanoparticles-in-microsphere oral system (NiMOS).

Polymeric nano- and microparticle technologies for oral gene delivery.

Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer.

Paclitaxel and ceramide co-administration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer.

Synthesis and evaluation of tripodal peptide analogues for cellular delivery of phosphopeptides.

Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations.

Role of nanotechnology in pharmaceutical product development.

Nanoparticulate carriers for the treatment of coronary restenosis.

Cytotoxicity and apoptosis enhancement in brain tumor cells upon coadministration of paclitaxel and ceramide in nanoemulsion formulations.

A review of stimuli-responsive nanocarriers for drug and gene delivery.

Poly(beta-amino ester) and cationic phospholipid-based lipopolyplexes for gene delivery and transfection in human aortic endothelial and smooth muscle cells.

Development of novel biodegradable polymeric nanoparticles-in-microsphere formulation for local plasmid DNA delivery in the gastrointestinal tract.

Enhanced mucosal and systemic immune response with squalane oil-containing multiple emulsions upon intranasal and oral administration in mice.

Enhancement in anti-proliferative effects of paclitaxel in aortic smooth muscle cells upon co-administration with ceramide using biodegradable polymeric nanoparticles.

Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles.

Multi-functional nanocarriers to overcome tumor drug resistance.

Multi-functional nanocarriers for targeted delivery of drugs and genes.

A model predicting delivery of saquinavir in nanoparticles to human monocyte/macrophage (Mo/Mac) cells.

Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model.

Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells.

Epidermal growth factor receptor-targeted gelatin-based engineered nanocarriers for DNA delivery and transfection in human pancreatic cancer cells.

Nanocarriers for systemic and mucosal vaccine delivery.

Coadministration of Paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells.

Challenges and opportunities in CNS delivery of therapeutics for neurodegenerative diseases.

Delivery strategies to enhance mucosal vaccination.

In vitro and in vivo studies of local arterial gene delivery and transfection using lipopolyplexes-embedded stents.

Brain delivery of proteins by the intranasal route of administration: a comparison of cationic liposomes versus aqueous solution formulations.

Label-free Raman spectral imaging of intracellular delivery and degradation of polymeric nanoparticle systems.

Nanotechnology solutions for infectious diseases in developing nations. Preface.

Nanotechnology-based systems for the treatment and prevention of HIV/AIDS.

Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma.

Nanoporous inorganic membranes or coatings for sustained drug delivery in implantable devices.

Nanotechnology solutions for mucosal immunization.

Sustained drug release from non-eroding nanoporous templates.

Nanoparticle-based endodontic antimicrobial photodynamic therapy.

Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles.

Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems.

Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields.

Nanoparticles: a promising modality in the treatment of sarcomas.

Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma.

Nanomedicine for cancer therapy.

Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation.

Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis.

A review of multifunctional nanoemulsion systems to overcome oral and CNS drug delivery barriers.

Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells.

Oral TNF-α gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease.

Preliminary evaluation of a nanotechnology-based approach for the more effective diagnosis of colon cancers.

Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer.

Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning.

Preparation and loading of gelatin nanoparticles.

Intracellular trafficking studies using gold-encapsulated gelatin nanoparticles.

Cell Transfection and Analysis Using DNA-Loaded Gelatin Nanoparticles.

Protein nanospheres for gene delivery.

Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology.

Mucoadhesive nanosystems for vaginal microbicide development: friend or foe?

Mucoadhesive nanomedicines: characterization and modulation of mucoadhesion at the nanoscale.

Non-condensing polymeric nanoparticles for targeted gene and siRNA delivery.

Anti-angiogenic effects of betulinic acid administered in nanoemulsion formulation using chorioallantoic membrane assay.

Combinatorial-designed multifunctional polymeric nanosystems for tumor-targeted therapeutic delivery.

Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer.

'Click' synthesis of dextran macrostructures for combinatorial-designed self-assembled nanoparticles encapsulating diverse anticancer therapeutics.

Therapeutic strategies for endothelial dysfunction.

Photodynamic effects of methylene blue-loaded polymeric nanoparticles on dental plaque bacteria.

Polymeric Nanoparticles Affect the Intracellular Delivery, Antiretroviral Activity and Cytotoxicity of the Microbicide Drug Candidate Dapivirine.

Fluorescence-guided optical coherence tomography imaging for colon cancer screening: a preliminary mouse study.

Multi-Compartmental Nanoparticles-in-Emulsion Formulation for Macrophage-Specific Anti-Inflammatory Gene Delivery.