Sunnybrook Research Institute,
Department of Biochemistry
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Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation.
Neoplasia (New York, N.Y.) Mar-Apr, 2002 | Pubmed ID: 11896570
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2003 | Pubmed ID: 12702765
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.
Genes & development Jul, 2003 | Pubmed ID: 12842910
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.
Cell Oct, 2004 | Pubmed ID: 15454081
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
Nature Oct, 2005 | Pubmed ID: 16148943
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18626018
The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.
Cell metabolism Sep, 2008 | Pubmed ID: 18762022
Using kinomics to delineate signaling pathways: control of CRTC2/TORC2 by the AMPK family.
Cell cycle (Georgetown, Tex.) Dec, 2008 | Pubmed ID: 19098422
Transcriptional activation by MEIS1A in response to protein kinase A signaling requires the transducers of regulated CREB family of CREB co-activators.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19473990
A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation.
EMBO reports Oct, 2009 | Pubmed ID: 19713961
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.
Cell metabolism Oct, 2009 | Pubmed ID: 19808021
Depletion of intranuclear rodlets in mouse models of diabetes.
Endocrine pathology Dec, 2010 | Pubmed ID: 20922502
Regulation of the CREB coactivator TORC by the dual leucine zipper kinase at different levels.
Cellular signalling Feb, 2011 | Pubmed ID: 20940047
Role of AMPK in pancreatic beta cell function.
Molecular and cellular endocrinology Feb, 2013 | Pubmed ID: 22766107
Glucose metabolism and pancreatic defects in spinal muscular atrophy.
Annals of neurology Aug, 2012 | Pubmed ID: 22926856
LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.
Human molecular genetics Mar, 2013 | Pubmed ID: 23187960
CRTC2 is required for β-cell function and proliferation.
Endocrinology Jul, 2013 | Pubmed ID: 23677932
Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.
Autophagy Nov, 2013 | Pubmed ID: 24005319
ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.
Science signaling , 2014 | Pubmed ID: 24473195
Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity.
Molecular and cellular biology Apr, 2014 | Pubmed ID: 24492964
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
Nature cell biology Mar, 2014 | Pubmed ID: 24561619
SGK1: master and commander of the fate of helper T cells.
Nature immunology May, 2014 | Pubmed ID: 24747705
Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.
Molecular and cellular biology Jan, 2015 | Pubmed ID: 25332238
High-content functional genomic screening to identify novel regulators of the PINK1-Parkin pathway.
Methods in enzymology , 2014 | Pubmed ID: 25416349
LKB1 couples glucose metabolism to insulin secretion in mice.
Diabetologia Jul, 2015 | Pubmed ID: 25874445
Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy.
Human molecular genetics Jun, 2015 | Pubmed ID: 26085578
To Be(ta Cell) or Not to Be(ta cell): New Mouse Models for Studying Gene Function in the Pancreatic β-Cell.
Endocrinology Jul, 2015 | Pubmed ID: 26091426
Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone.
Diabetes Jul, 2015 | Pubmed ID: 26153246
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