Rupert Handgretinger

Alpha-CD25 antibody treatment in a child with hemophagocytic lymphohistiocytosis.

CD34 stem cell dose and development of extensive chronic graft-versus-host disease.

Gene therapy for severe combined immunodeficiency disease.

Summary of symposium: the future of stem cell transplantation for sickle cell disease.

Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia.

Identification of a novel class of human adherent CD34- stem cells that give rise to SCID-repopulating cells.

Bone marrow-derived factors support growth of N-type, but not of melanocytic neuroblastoma cells.

Megadose transplantation of highly purified haploidentical stem cells: current results and future prospects.

Receptor activator of nuclear factor kappaB ligand plays a nonredundant role in doxorubicin-induced apoptosis.

Biology and plasticity of CD133+ hematopoietic stem cells.

T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation.

Etiology and outcome of graft failure in pediatric hematopoietic stem cell transplant recipients.

Possible allogeneic graft-versus-tumor effect in childhood melanoma.

Transplantation of a combination of CD133+ and CD34+ selected progenitor cells from alternative donors.

Determinants of antileukemia effects of allogeneic NK cells.

Malignant infantile osteopetrosis and primary pulmonary hypertension: a new combination?

Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients who received T-cell-depleted allografts.

Successful treatment of primary refractory acute myeloid leukemia with megadose stem cell transplantation, bone marrow boost and reduced intensity conditioning avoiding chronic graft vs. host disease and severe late toxicity.

Cytotoxic activity of natural killer cells lacking killer-inhibitory receptors for self-HLA class I molecules against autologous hematopoietic stem cells in healthy individuals.

Transplantation of highly purified CD34+ progenitor cells from alternative donors in children with refractory severe aplastic anaemia.

Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell transplantation: possible role for pre-emptive immunotherapy?

Levels of total fungus and Aspergillus on a pediatric hematopoietic stem cell transplant unit.

Human CD4+CD25+ regulatory T cells share equally complex and comparable repertoires with CD4+CD25- counterparts.

Haploidentical transplantation for acute lymphoblastic leukemia in childhood.

Impaired T-cell activation and cytokine productivity after transplantation of positively selected CD34+ allogeneic hematopoietic stem cells.

Consolidation treatment with chimeric anti-GD2-antibody ch14.18 in children older than 1 year with metastatic neuroblastoma.

Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients.

Phenotype and function of human natural killer cells purified by using a clinical-scale immunomagnetic method.

Long-term outcome after haploidentical stem cell transplantation in children.

Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation.

Graft-versus-Ewing sarcoma effect and long-term remission induced by haploidentical stem-cell transplantation in a patient with relapse of metastatic disease.

Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation.

Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction.

Experiences with haploidentical stem cell transplantation in children with acute lymphoblastic leukemia.

Allogeneic graft-versus-hepatoblastoma effect.

Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease.

Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.

Comparison of killer Ig-like receptor genotyping and phenotyping for selection of allogeneic blood stem cell donors.

Outcome of hematopoietic stem cell transplantation for pediatric patients with therapy-related acute myeloid leukemia or myelodysplastic syndrome.

Hemolytic uremic syndrome after bone marrow transplantation: clinical characteristics and outcome in children.

Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma.

EBV lymphoproliferative disease of host origin after haploidentical stem cell transplantation.

KIR-incompatible hematopoietic-cell transplantation for poor prognosis infant acute lymphoblastic leukemia.

The role of graft-versus-host disease in the inhibition of normal B-lymphopoiesis and leukemic control of B-lineage acute lymphocytic leukemia after allogeneic stem cell transplantation.

Cidofovir for the treatment of adenoviral infection in pediatric hematopoietic stem cell transplant patients.

Outcome of allogeneic stem cell transplantation in children with non-malignant diseases.

Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation.

Pitfalls in detection of contaminating neuroblastoma cells by tyrosine hydroxylase RT-PCR due to catecholamine-producing hematopoietic cells.

Efficient and reproducible large-scale isolation of human CD4+ CD25+ regulatory T cells with potent suppressor activity.

Diagnostic challenge in recurrent skin rash after autologous bone marrow transplantation.

Immune reconstitution after purified autologous and allogeneic blood stem cell transplantation compared with unmanipulated bone marrow transplantation in children.

Increased alpha2,6-sialylation of surface proteins on tolerogenic, immature dendritic cells and regulatory T cells.

In vitro analysis of multipotent mesenchymal stromal cells as potential cellular therapeutics in neurometabolic diseases in pediatric patients.

Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies.

Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation.

Haploidentical allogeneic hematopoietic cell transplantation in adults with reduced-intensity conditioning and CD3/CD19 depletion: fast engraftment and low toxicity.

Adenovirus infection after allogeneic stem cell transplantation.

Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation.

Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expression.

Intensity of HLA class I expression and KIR-mismatch determine NK-cell mediated lysis of leukaemic blasts from children with acute lymphatic leukaemia.

A novel approach for the analysis of T-cell reconstitution by using a T-cell receptor beta-based oligonucleotide microarray in hematopoietic stem cell transplantation.

Diagnostic yield of bronchoalveolar lavage is low in allogeneic hematopoietic stem cell recipients receiving immunosuppressive therapy or with acute graft-versus-host disease: the St. Jude experience, 1990-2002.

Beyond the FACS.

Immunosuppressive total lymphoid irradiation-based reconditioning regimens enable engraftment after graft rejection or graft failure in patients treated with allogeneic hematopoietic stem cell transplantation.

Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: an update.

Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantation.

Retransplantation with stem cells from mismatched related donors after graft rejection in pediatric patients.

WT1 protein expression in childhood acute leukemia.

Indications and donor selections for allogeneic stem cell transplantation in children with hematologic malignancies.

Five donors-one recipient: modeling a mosaic of granulocytes, natural killer and T cells from cord-blood and third-party donors.

WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G0/G1 phase.

Molecular monitoring of immune reconstitution after haploidentical stem cell transplantation.

Leucoencephalopathy, transverse myelopathy, and peripheral neuropathy in association with glutamic acid decarboxylase-65 (GAD) antibodies in children with cancer.

Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation.

Mesenchymal stromal cells: a novel treatment option for steroid-induced avascular osteonecrosis.

Immune response of human propagated gammadelta-T-cells to neuroblastoma recommend the Vdelta1+ subset for gammadelta-T-cell-based immunotherapy.

Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group.

Total and active rabbit antithymocyte globulin (rATG;Thymoglobulin) pharmacokinetics in pediatric patients undergoing unrelated donor bone marrow transplantation.

Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia.

Dendritic cells: functional aspects of glycosylation and lectins.

Clinical utility of computed tomography screening of chest, abdomen, and sinuses before hematopoietic stem cell transplantation: the St. Jude experience.

Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter-expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells.

Highlights of the First International "Immunotherapy in Pediatric Oncology: Progress and Challenges" Meeting.

Adult stem cells as an alternative source of multipotential (pluripotential) cells in regenerative medicine.

Dynamics of the emergence of a human cytomegalovirus UL97 mutant strain conferring ganciclovir resistance in a pediatric stem-cell transplant recipient.

Treating childhood acute lymphoblastic leukemia without cranial irradiation.

Preservation of immune repertoire by selective depletion of haploidentical grafts.

Ex vivo detection of adenovirus specific CD4+ T-cell responses to HLA-DR-epitopes of the Hexon protein show a contracted specificity of T(HELPER) cells following stem cell transplantation.

Chronic inflammatory bowel disease as key manifestation of atypical ARTEMIS deficiency.

Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group.

Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells.

Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children.

Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia.

Dendritic cell vaccination in an allogeneic stem cell recipient receiving a transplant from a human cytomegalovirus (HCMV)-seronegative donor: induction of a HCMV-specific T(helper) cell response.

Immunotherapy in the context of hematopoietic stem cell transplantation: the emerging role of natural killer cells and mesenchymal stromal cells.

High frequency of immature cells at diagnosis predicts high minimal residual disease level in childhood acute lymphoblastic leukemia.

H(2)O(2)-mediated cytotoxicity of pharmacologic ascorbate concentrations to neuroblastoma cells: potential role of lactate and ferritin.

Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation.

Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells.

Long-term human CD34+ stem cell-engrafted nonobese diabetic/SCID/IL-2R gamma(null) mice show impaired CD8+ T cell maintenance and a functional arrest of immature NK cells.

Establishment of a rhabdomyosarcoma xenograft model in human-adapted mice.

Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity.

Donor selection for AML: do the KIR.

Point-counterpoint: haploidentical family donors versus cord blood transplantation.

High proportion of leukemic stem cells at diagnosis is correlated with unfavorable prognosis in childhood acute myeloid leukemia.

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice.

Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy.

Long-term remission after first-line single-agent treatment with arsenic trioxide of relapsed acute promyelocytic leukemia in an 8-year-old boy.

Impaired tumor rejection by memory CD8 T cells in mice with NKG2D dysfunction.

High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia.

CD155 is involved in NK-cell mediated lysis of human hepatoblastoma in vitro.

Highlights of the second international conference on "Immunotherapy in Pediatric Oncology".

Natural killer cell activity influences outcome after T cell depleted stem cell transplantation from matched unrelated and haploidentical donors.

Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children.

Comparison of different adjuvant radiotherapy approaches in childhood bladder/prostate rhabdomyosarcoma treated with conservative surgery.

Extended hepatic resection in advanced hepatoblastoma.

Haploidentical stem cell transplantation for children with high-risk leukemia.

Surgical treatment of lung metastases in patients with embryonal pediatric solid tumors: an update.

New strategies for haploidentical transplantation.

Monocytes derived from humanized neonatal NOD/SCID/IL2Rγ(null) mice are phenotypically immature and exhibit functional impairments.

Bacterial reprogramming of PBMCs impairs monocyte phagocytosis and modulates adaptive T cell responses.

Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: a phase II study.

Influence of dichloroacetate (DCA) on lactate production and oxygen consumption in neuroblastoma cells: is DCA a suitable drug for neuroblastoma therapy?

Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia.

Surgical management of stem cell transplantation-related complications in children.

Siglec-7 tetramers characterize B-cell subpopulations and leukemic blasts.

Alternative donor HSCT in refractory acquired aplastic anemia: the time has come.

Characterisation of the cell line HC-AFW1 derived from a pediatric hepatocellular carcinoma.

Caspofungin as antifungal prophylaxis in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis.

Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation.

Negative depletion of CD3(+) and TcRαβ(+) T cells.

Suicidal T cells: a jump-start for the thymus.

Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation.

Induction of Thelper1-driven antiviral T-cell lines for adoptive immunotherapy is determined by differential expression of IFN-γ and T-cell activation markers.

CD133-Positive Hematopoietic Stem Cells: From Biology to Medicine.

Adoptive transfer of epstein-barr virus (EBV) nuclear antigen 1-specific t cells as treatment for EBV reactivation and lymphoproliferative disorders after allogeneic stem-cell transplantation.

New approaches to graft engineering for haploidentical bone marrow transplantation.

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.

Eradication of pulmonary aspergillosis in an adolescent patient undergoing three allogeneic stem cell transplantations for acute lymphoblastic leukemia.

Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease.

Innate immune defense defines susceptibility of sarcoma cells to measles vaccine virus-based oncolysis.

T-helper-1-cell cytokines drive cancer into senescence.

Treatment of liver transplant graft-versus-host disease with antibodies against tumor necrosis factor-α.

Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism.

CAReful epitope selection matters.

Influence of a mutation in IFN-γ receptor 2 (IFNGR2) in human cells on the generation of Th17 cells in memory T cells.

One goal, different strategies--molecular and cellular approaches for the treatment of inherited skin fragility disorders.

Engraftment of low numbers of pediatric acute lymphoid and myeloid leukemias into NOD/SCID/IL2Rcγnull mice reflects individual leukemogenecity and highly correlates with clinical outcome.

Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia.

Depletion of T-cell receptor alpha/beta and CD19 positive cells from apheresis products with the CliniMACS device.

Therapy response correlates with ALDH activity in ALDH low-positive childhood acute lymphoblastic leukemias.

Inadvertent intravenous administration of maternal breast milk in a six-week-old infant: a case report and review of the literature.

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1.

Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia.

Haploidentical stem cell transplantation in DOCK8 deficiency - Successful control of pre-existing severe viremia with a TCRaß/CD19-depleted graft and antiviral treatment.

Combined PET/MR: Where are we now? Summary report of the second international workshop on PET/MR imaging April 8-12, 2013, Tubingen, Germany.

In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival.

Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma.

Pediatric posttransplant relapsed/refractory B-precursor acute lymphoblastic leukemia shows durable remission by therapy with the T-cell engaging bispecific antibody blinatumomab.

KIR haplotype B donors but not KIR-ligand mismatch result in a reduced incidence of relapse after haploidentical transplantation using reduced intensity conditioning and CD3/CD19-depleted grafts.

Synthesis and biological effects of new hybrid compounds composed of benzylguanidines and the alkylating group of busulfan on neuroblastoma cells.

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders.

A newborn with grouped facial skin lesions and subsequent seizures.

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.

How an accidental discovery paved the way for the treatment of complicated infantile haemangiomas.

Will post-transplantation cell therapies for pediatric patients become standard of care?

Haploidentical transplantation: the search for the best donor.

Human leukocyte antigen DR surface expression on CD14+ monocytes during adverse events after hematopoietic stem cell transplantation.

KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL.

Monocyte-induced development of Th17 cells and the release of S100 proteins are involved in the pathogenesis of graft-versus-host disease.

Tumour volume reduction after neoadjuvant chemotherapy impacts outcome in localised embryonal rhabdomyosarcoma.

Both mature KIR+ and immature KIR- NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdcscid IL2rgtmWjl/Sz mice.

γδ T Cell-Mediated Antibody-Dependent Cellular Cytotoxicity with CD19 Antibodies Assessed by an Impedance-Based Label-Free Real-Time Cytotoxicity Assay.

Phagocytic activity of monocytes, their subpopulations and granulocytes during post-transplant adverse events after hematopoietic stem cell transplantation.

Arabinoxylan rice bran (MGN-3/Biobran) enhances natural killer cell-mediated cytotoxicity against neuroblastoma in vitro and in vivo.

Patterns of monocyte subpopulations and their surface expression of HLA-DR during adverse events after hematopoietic stem cell transplantation.

A functional inflammasome activation assay differentiates patients with pathogenic NLRP3 mutations and symptomatic patients with low penetrance variants.

Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT.

Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells.

Simultaneous Resection of High-risk Liver Tumors and Pulmonary Metastases in Children.

Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.

High Local Concentrations of Intradermal MSCs Restore Skin Integrity and Facilitate Wound Healing in Dystrophic Epidermolysis Bullosa.

Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells.

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency.

No association between the presence of killer-cell immunoglobulin-like receptor genes and susceptibility to childhood ALL.

Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation.

Chronic graft-versus-host-disease in CD34(+)-humanized NSG mice is associated with human susceptibility HLA haplotypes for autoimmune disease.

Rapid generation of NY-ESO-1-specific CD4(+) THELPER1 cells for adoptive T-cell therapy.

Nifurtimox reduces N-Myc expression and aerobic glycolysis in neuroblastoma.

NKG2D Signaling Leads to NK Cell Mediated Lysis of Childhood AML.

Preemptive administration of human αβ T cell receptor-targeting monoclonal antibody GZ-αβTCR potently abrogates aggressive graft-versus-host disease in vivo.

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.

Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation.

Enriched Bone Marrow Derived Disseminated Neuroblastoma Cells Can Be a Reliable Source for Gene Expression Studies-A Validation Study.

Posaconazole plasma concentration in pediatric patients receiving antifungal prophylaxis after allogeneic hematopoietic stem cell transplantation.

Hoechst 33342 Staining Identifies the Progenitor Side Population in NOD.Cg-PrkdcscidIL2rgtmWjl/Sz Mice Harboring Pediatric Leukemias.

Modified mRNA as a new therapeutic option for pediatric respiratory diseases and hemoglobinopathies.

Ferritin as an early marker of graft rejection after allogeneic hematopoietic stem cell transplantation in pediatric patients.