JoVE Logo
Authors
Contact Us

Sign In

Core - Pharmacokinetics and Pharmacodynamics

    Chapter 8

    Nonlinear Pharmacokinetics

    8.1 : Nonlinear Pharmacokinetics: Overview01:19

    8.1 : Nonlinear Pharmacokinetics: Overview

    Nonlinear pharmacokinetics, or dose-dependent kinetics, manifests when certain drugs deviate from linear behavior at higher doses, not to follow ...

    278 views
    8.2 : Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

    8.2 : Nonlinear Pharmacokinetics: Causes of Nonlinearity

    Various factors contribute to nonlinearity in drug pharmacokinetics. Nonlinearity in drug absorption may result from rate-limited solubility, ...

    129 views
    8.3 : Nonlinear Pharmacokinetics: Michaelis-Menten Equation01:18

    8.3 : Nonlinear Pharmacokinetics: Michaelis-Menten Equation

    The Michaelis-Menten equation describes capacity-limited kinetics in drug metabolism. It determines the rate of decline of drug concentration over time, ...

    240 views
    8.4 : Determination of Michaelis Constant and Maximum Elimination Rate01:20

    8.4 : Determination of Michaelis Constant and Maximum Elimination Rate

    The Michaelis-Menten equation parameters–Michaelis constant, KM, and the maximum process rate, Vmax – are estimated post-drug administration. ...

    66 views
    8.5 : Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection00:59

    8.5 : Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection

    In capacity-limited pharmacokinetics, drug elimination is influenced by Vmax and KM. Following an IV bolus, Dt, the amount of drug in the body at any ...

    42 views
    8.6 : Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview01:25

    8.6 : Drug Distribution as One-Compartment Model and Elimination by Nonlinear Pharmacokinetics: Overview

    Drug administration through various routes results in mixed drug elimination, involving both nonlinear and linear processes. The metabolism of drugs ...

    45 views
    8.7 : Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

    8.7 : Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

    Drugs administered through different administration routes follow nonlinear elimination. Consider a drug administered through a constant IV infusion, ...

    45 views
    8.8 : Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

    8.8 : Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

    Drug elimination half-life and clearance vary with dosage or concentration in nonlinear kinetics. The elimination half-life is influenced by the ...

    84 views
    8.9 : Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

    8.9 : Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

    Circadian rhythms influence cyclic changes in plasma drug concentrations through regular fluctuations in physiological functions. Standard circadian ...

    43 views
    8.10 : Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

    8.10 : Chronopharmacokinetics: Time-Dependent Pharmacokinetics

    Chronopharmacokinetics studies the temporal change in drug absorption and elimination, whether cyclical or noncyclical. Cyclic changes occur over constant ...

    90 views
    8.11 : Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding01:22

    8.11 : Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding

    For drugs that follow nonlinear pharmacokinetics, the absorption, distribution, and elimination processes may potentially saturate. A saturable pathway ...

    121 views
    8.12 : Nonlinear Pharmacokinetics: Role of Transporters01:27

    8.12 : Nonlinear Pharmacokinetics: Role of Transporters

    Drug kinetics, under nonlinear changes influenced by transporter proteins, are pivotal in drug distribution. These cellular transporters in cells modulate ...

    33 views
    JoVE Logo

    Privacy

    Terms of Use

    Policies

    Contact Us

    Recommend to library

    JoVE NEWSLETTERS

    Research

    Education

    Authors

    Librarians

    ABOUT JoVE

    Copyright © 2025 MyJoVE Corporation. All rights reserved