Mark W. Dewhirst

Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity.

Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.

Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.

Method for improved accuracy in endogenous urea recovery marker calibrations for microdialysis in tumors.

Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient.

Thermal dose is related to duration of local control in canine sarcomas treated with thermoradiotherapy.

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.

A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.

In regard to Vasanathan et al. (Int J Radiat Oncol Biol Phys 2005;61:145-153).

Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development.

In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212).

A comparison of antiangiogenic therapies for the prevention of liver metastases.

Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data.

Thermal medicine, heat shock proteins and cancer.

Re-setting the biologic rationale for thermal therapy.

Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity.

Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity.

New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme.

Erythropoietin biology in cancer.

A unique role of the DNA fragmentation factor in maintaining genomic stability.

Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy.

Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor.

Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity.

Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.

The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma.

Monitoring metabolite gradients in the blood, liver, and tumor after induced hyperglycemia in rats with R3230 flank tumors using microdialysis and bioluminescence imaging.

Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay.

The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis.

Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone).

Hyperthermia mediated liposomal drug delivery.

Prospective thermal dosimetry: the key to hyperthermia's future.

Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy.

Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma.

Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors.

Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury.

Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.

Alternative inclusion of fibroblast growth factor receptor 2 exon IIIc in Dunning prostate tumors reveals unexpected epithelial mesenchymal plasticity.

Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy.

Chemodosimetry of in vivo tumor liposomal drug concentration using MRI.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct.

A tracer dose of technetium-99m-labeled liposomes can estimate the effect of hyperthermia on intratumoral doxil extravasation.

Tumor necrosis factor-alpha is a potent endogenous mutagen that promotes cellular transformation.

Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects.

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury.

Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions.

A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas.

Multiple etiologies of tumor hypoxia require multifaceted solutions.

Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.

An in vitro system to evaluate the effects of ischemia on survival of cells used for cell therapy.

Regulation of HIF-1alpha stability through S-nitrosylation.

Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth.

Hypoxia and radiotherapy: opportunities for improved outcomes in cancer treatment.

Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors.

Targeting the molecular effects of a hypoxic tumor microenvironment.

Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase.

In memoriam: Edward L Gillette (1932-2006).

Requirements for T lymphocyte migration in explanted lymph nodes.

Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.

The potential role of intrinsic hypoxia markers as prognostic variables in cancer.

Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression.

Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.

Predicting lung radiotherapy-induced pneumonitis using a model combining parametric Lyman probit with nonparametric decision trees.

RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin.

Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer.

Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation.

Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model.

Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan.

PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator.

Rationale for and measurement of liposomal drug delivery with hyperthermia using non-invasive imaging techniques.

Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder.

Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors.

Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors.

One-stop-shop tumor imaging: buy hypoxia, get lactate free.

Bromelain treatment decreases neutrophil migration to sites of inflammation.

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response.

Induction of the human heat shock promoter HSP70B by nutritional stress: implications for cancer gene therapy.

Low-intensity alternating electric fields: a potentially safe and effective treatment of cancer?

Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome.

Radiofrequency ablation: the effect of distance and baseline temperature on thermal dose required for coagulation.

The pervasive presence of fluctuating oxygenation in tumors.

Hyperthermia and nanotechnology - a note from the Editor-in-chief.

Estrogen-related receptor alpha is critical for the growth of estrogen receptor-negative breast cancer.

In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.

Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B.

Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging.

Hyperthermia classic commentary: 'Arrhenius relationships from the molecule and cell to the clinic' by William Dewey, Int. J. Hyperthermia, 10:457-483, 1994.

Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer.

The performance of a reduced-order adaptive controller when used in multi-antenna hyperthermia treatments with nonlinear temperature-dependent perfusion.

Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.

Quantitative diffuse reflectance and fluorescence spectroscopy: tool to monitor tumor physiology in vivo.

Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.

Structural adaptation and heterogeneity of normal and tumor microvascular networks.

Novel imaging provides new insights into mechanisms of oxygen transport in tumors.

Increased skin carcinogenesis in caspase-activated DNase knockout mice.

Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer.

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor.

Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy.

DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study.

Characterization of a 137Cs irradiator from a new perspective with modern dosimetric tools.

A dual-emissive-materials design concept enables tumour hypoxia imaging.

Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors.

Quantitative optical spectroscopy can identify long-term local tumor control in irradiated murine head and neck xenografts.

Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy.

Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress.

Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer.

Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas.

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.

Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy.

Longitudinal optical imaging of tumor metabolism and hemodynamics.

Application of mixed spin iMQCs for temperature and chemical-selective imaging.

A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer.

Mathematical formulation and analysis of the nonlinear system reconstruction of the online image-guided adaptive control of hyperthermia.

Effective learning strategies for real-time image-guided adaptive control of multiple-source hyperthermia applicators.

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.

Effect of pazopanib on tumor microenvironment and liposome delivery.

Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours.

The shunt problem: control of functional shunting in normal and tumour vasculature.

A feasibility study using radiochromic films for fast neutron 2D passive dosimetry.

Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.

Low-carbohydrate diets and prostate cancer: how low is "low enough"?

Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity.

Individual responses to chemotherapy-induced oxidative stress.

Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data.

Hyperthermia for locally advanced breast cancer.

Magnetic resonance imaging: a potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer.

Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site.

NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.

Durable palliation of breast cancer chest wall recurrence with radiation therapy, hyperthermia, and chemotherapy.

Optical imaging of tumor hypoxia dynamics.

Molecular imaging of hypoxia.

Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors.

Comparison of genomics and functional imaging from canine sarcomas treated with thermoradiotherapy predicts therapeutic response and identifies combination therapeutics.

Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound.

ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells.

Thresholds for thermal damage to normal tissues: an update.

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes.

In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide.

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.

In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters.

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.

Structural adaptation of normal and tumour vascular networks.

Introduction to the special issue on molecular imaging in radiation biology.

Application of optical imaging and spectroscopy to radiation biology.

Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma.

Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer.

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.

Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma.

Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer.

Effects and potential mechanisms of exercise training on cancer progression: a translational perspective.

A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion.

Miniature microwave applicator for murine bladder hyperthermia studies.

High-resolution in vivo imaging of fluorescent proteins using window chamber models.

A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5).

Thermal dose fractionation affects tumour physiological response.

Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.

Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways.

Measuring tumor cycling hypoxia and angiogenesis using a side-firing fiber optic probe.

Sickle erythrocytes target cytotoxics to hypoxic tumor microvessels and potentiate a tumoricidal response.

The impact of temperature and urinary constituents on urine viscosity and its relevance to bladder hyperthermia treatment.

Radiation induces aerobic glycolysis through reactive oxygen species.

CEM43°C thermal dose thresholds: a potential guide for magnetic resonance radiofrequency exposure levels?

Angiogenesis: an adaptive dynamic biological patterning problem.

Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose.

Novel approaches to treatment of hepatocellular carcinoma and hepatic metastases using thermal ablation and thermosensitive liposomes.

A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.

18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model.

Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm.

Nanoscale Drug Delivery and Hyperthermia: The Materials Design and Preclinical and Clinical Testing of Low Temperature-Sensitive Liposomes Used in Combination with Mild Hyperthermia in the Treatment of Local Cancer.

Preclinical Dosimetry of Magnetic Fluid Hyperthermia for Bladder Cancer.

Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.

A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment.

Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia.

A method to convert MRI images of temperature change into images of absolute temperature in solid tumours.

Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.

Hypoxia in melanoma: using optical spectroscopy and EF5 to assess tumor oxygenation before and during regional chemotherapy for melanoma.

Introduction: tumor as an organ.

Understanding the tumor microenvironment and radioresistance by combining functional imaging with global gene expression.

Magnetic fluid hyperthermia for bladder cancer: a preclinical dosimetry study.

Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer.

PET with 62Cu-ATSM and 62Cu-PTSM is a useful imaging tool for hypoxia and perfusion in pulmonary lesions.

Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer.

Imaging tumor hypoxia to advance radiation oncology.

Control time reduction using virtual source projection for treating a leg sarcoma with nonlinear perfusion.

Rationalization of thermal injury quantification methods: application to skin burns.

Temperature matters! And why it should matter to tumor immunologists.

A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer.

Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators.

Therapeutic properties of aerobic training after a cancer diagnosis: more than a one-trick pony?

Targeting N-cadherin Increases Vascular Permeability and Differentially Activates AKT in Melanoma.

Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer.

The additive damage model: a mathematical model for cellular responses to drug combinations.

Linking the history of radiation biology to the hallmarks of cancer.

Comparison of the Hypoxia PET Tracer 18F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models.

Verification of a novel method for tube voltage constancy measurement of orthovoltage x-ray irradiators.

Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer.

Systemic anti-tumour effects of local thermally sensitive liposome therapy.

Radioprotection of the brain white matter by Mn(III) N-butoxyethylpyridylporphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+