Division of Molecular Oncology
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Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22.
European journal of immunology May, 2002 | Pubmed ID: 11981828
Chronic B cell malignancies and bone marrow microenvironment.
Seminars in cancer biology Apr, 2002 | Pubmed ID: 12027587
CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells.
British journal of haematology Nov, 2002 | Pubmed ID: 12406091
CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes.
Blood Mar, 2003 | Pubmed ID: 12406905
The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression.
Blood Feb, 2003 | Pubmed ID: 12406914
Chronic lymphocytic leukaemia: a model for investigating potential new targets for the therapy of indolent lymphomas.
Best practice & research. Clinical haematology Sep, 2002 | Pubmed ID: 12468406
Expansion of tumor-specific CD8+ T cell clones in patients with relapsed myeloma after donor lymphocyte infusion.
Cancer research May, 2003 | Pubmed ID: 12750280
The characterization of chemokine production and chemokine receptor expression reveals possible functional cross-talks in AML blasts with monocytic differentiation.
Experimental hematology Jun, 2003 | Pubmed ID: 12829025
IL-12 regulates an endothelial cell-lymphocyte network: effect on metalloproteinase-9 production.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2003 | Pubmed ID: 14500672
Monoclonal CD5+ and CD5- B-lymphocyte expansions are frequent in the peripheral blood of the elderly.
Blood Mar, 2004 | Pubmed ID: 14630808
Leukemia-derived immature dendritic cells differentiate into functionally competent mature dendritic cells that efficiently stimulate T cell responses.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2004 | Pubmed ID: 15295005
The nature and origin of the B-chronic lymphocytic leukemia cell: a tentative model.
Hematology/oncology clinics of North America Aug, 2004 | Pubmed ID: 15325702
Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene.
Blood Feb, 2005 | Pubmed ID: 15466924
Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid.
Cancer research Dec, 2004 | Pubmed ID: 15604289
HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses.
The Journal of clinical investigation Jun, 2005 | Pubmed ID: 15931393
Diagnostic criteria for monoclonal B-cell lymphocytosis.
British journal of haematology Aug, 2005 | Pubmed ID: 16042682
Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia.
Cancer research Nov, 2005 | Pubmed ID: 16267031
The origin of B-cell chronic lymphocytic leukemia.
Seminars in oncology Apr, 2006 | Pubmed ID: 16616061
IGHV gene insertions and deletions in chronic lymphocytic leukemia: "CLL-biased" deletions in a subset of cases with stereotyped receptors.
European journal of immunology Jul, 2006 | Pubmed ID: 16783849
Evaluation of ZAP-70 expression by flow cytometry in chronic lymphocytic leukemia: A multicentric international harmonization process.
Cytometry. Part B, Clinical cytometry Jul, 2006 | Pubmed ID: 16906588
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: Pathogenetic implications and clinical correlations.
Blood Jan, 2007 | Pubmed ID: 16985177
Chronic lymphocytic leukemia.
Critical reviews in oncology/hematology Dec, 2007 | Pubmed ID: 17544290
The normal counterpart to the chronic lymphocytic leukemia B cell.
Best practice & research. Clinical haematology Sep, 2007 | Pubmed ID: 17707828
A woman and her canary: a tale of chlamydiae and lymphomas.
Journal of the National Cancer Institute Sep, 2007 | Pubmed ID: 17848672
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis.
Blood Feb, 2008 | Pubmed ID: 17959859
Overview of monoclonal B-cell lymphocytosis.
British journal of haematology Dec, 2007 | Pubmed ID: 18021084
Age-dependent accumulation of monoclonal CD4+CD8+ double positive T lymphocytes in the peripheral blood of the elderly.
British journal of haematology Dec, 2007 | Pubmed ID: 18021092
From normal to clonal B cells: Chronic lymphocytic leukemia (CLL) at the crossroad between neoplasia and autoimmunity.
Autoimmunity reviews Dec, 2007 | Pubmed ID: 18035322
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy.
Blood Jul, 2008 | Pubmed ID: 18292287
Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Sep, 2008 | Pubmed ID: 18662968
Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia.
Blood Jan, 2009 | Pubmed ID: 18948572
The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring.
Blood Jul, 2009 | Pubmed ID: 19029437
Expression and function of toll like receptors in chronic lymphocytic leukaemia cells.
British journal of haematology Feb, 2009 | Pubmed ID: 19036098
B-cell clones as early markers for chronic lymphocytic leukemia.
The New England journal of medicine Feb, 2009 | Pubmed ID: 19213679
Introduction to Chronic Lymphocytic Leukemia Young Investigator's Meeting.
Leukemia & lymphoma Mar, 2009 | Pubmed ID: 19347731
Monoclonal B lymphocytosis in the general population.
Leukemia & lymphoma Mar, 2009 | Pubmed ID: 19347732
The microenvironment in mature B-cell malignancies: a target for new treatment strategies.
Blood Oct, 2009 | Pubmed ID: 19636060
Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study.
Blood Dec, 2009 | Pubmed ID: 19828698
A novel Rag2-/-gammac-/--xenograft model of human CLL.
Blood Feb, 2010 | Pubmed ID: 20018917
MicroRNA and proliferation control in chronic lymphocytic leukemia: functional relationship between miR-221/222 cluster and p27.
Blood May, 2010 | Pubmed ID: 20203269
HS1 has a central role in the trafficking and homing of leukemic B cells.
Blood Nov, 2010 | Pubmed ID: 20530793
ZAP-70 expression is associated with increased risk of autoimmune cytopenias in CLL patients.
American journal of hematology Jul, 2010 | Pubmed ID: 20575031
How the microenvironment shapes chronic lymphocytic leukemia: the cytoskeleton connection.
Leukemia & lymphoma Aug, 2010 | Pubmed ID: 20687794
CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it?
Seminars in cancer biology Dec, 2010 | Pubmed ID: 20816789
Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL).
Cytometry. Part B, Clinical cytometry , 2010 | Pubmed ID: 20839333
Commentary: Comparison of current flow cytometry methods for monoclonal B cell lymphocytosis detection.
Cytometry. Part B, Clinical cytometry , 2010 | Pubmed ID: 20839336
Monoclonal B cell lymphocytosis in hepatitis C virus infected individuals.
Cytometry. Part B, Clinical cytometry , 2010 | Pubmed ID: 20839339
Inherited genetic susceptibility to monoclonal B-cell lymphocytosis.
Blood Dec, 2010 | Pubmed ID: 20855867
Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2011 | Pubmed ID: 21189302
In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor.
Blood May, 2011 | Pubmed ID: 21406718
Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models.
Blood Jul, 2011 | Pubmed ID: 21652674
Toll-like receptor signaling pathway in chronic lymphocytic leukemia: distinct gene expression profiles of potential pathogenic significance in specific subsets of patients.
Haematologica Nov, 2011 | Pubmed ID: 21750087
Is there a role for antigen selection in mantle cell lymphoma? Immunogenetic support from a series of 807 cases.
Blood Sep, 2011 | Pubmed ID: 21791422
Another piece of the puzzle: is there a "nodal" monoclonal B-cell lymphocytosis?
Haematologica Aug, 2011 | Pubmed ID: 21810972
General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL.
Blood Dec, 2011 | Pubmed ID: 21876118
Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies.
Blood May, 2012 | Pubmed ID: 22415752
Monoclonal B-cell lymphocytosis: right track or red herring?
Blood May, 2012 | Pubmed ID: 22422819
KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia.
Epigenetics : official journal of the DNA Methylation Society Mar, 2012 | Pubmed ID: 22430796
Distinct innate immunity pathways to activation and tolerance in subgroups of chronic lymphocytic leukemia with distinct immunoglobulin receptors.
Molecular medicine (Cambridge, Mass.) , 2012 | Pubmed ID: 22437326
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.
Blood May, 2012 | Pubmed ID: 22452978
Changes in the apoptotic gene expression profile in CLL patients treated with rituximab combined with cladribine and cyclophosphamide-preliminary results.
Leukemia research Sep, 2012 | Pubmed ID: 22608309
Bone marrow histopathology in the diagnostic evaluation of splenic marginal-zone and splenic diffuse red pulp small B-cell lymphoma: a reliable substitute for spleen histopathology?
The American journal of surgical pathology Nov, 2012 | Pubmed ID: 23073320
In vitro sensitivity of CLL cells to fludarabine may be modulated by the stimulation of Toll-like receptors.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2013 | Pubmed ID: 23224401
A look into the future: can minimal residual disease guide therapy and predict prognosis in chronic lymphocytic leukemia?
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program , 2012 | Pubmed ID: 23233566
Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia.
Blood Mar, 2013 | Pubmed ID: 23325840
Targeting B-cell anergy in chronic lymphocytic leukemia.
Blood May, 2013 | Pubmed ID: 23460614
MBL versus CLL: how important is the distinction?
Hematology/oncology clinics of North America Apr, 2013 | Pubmed ID: 23561472
Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL.
Blood May, 2013 | Pubmed ID: 23596047
Differential microRNA profiles and their functional implications in different immunogenetic subsets of chronic lymphocytic leukemia.
Molecular medicine (Cambridge, Mass.) , 2013 | Pubmed ID: 23615967
Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America May, 2013 | Pubmed ID: 23630276
Antigen selection in B-cell lymphomas--tracing the evidence.
Seminars in cancer biology Dec, 2013 | Pubmed ID: 23932942
Monoclonal B cell lymphocytosis and "in situ" lymphoma.
Seminars in cancer biology Feb, 2014 | Pubmed ID: 23999128
Reprogramming cell death: BCL2 family inhibition in hematological malignancies.
Immunology letters Sep-Oct, 2013 | Pubmed ID: 24095849
IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2014 | Pubmed ID: 24240110
Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding.
Blood Feb, 2014 | Pubmed ID: 24345750
The microenvironment in lymphomas--dissecting the complex crosstalk between tumor cells and 'by-stander' cells.
Seminars in cancer biology Feb, 2014 | Pubmed ID: 24365642
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia.
The New England journal of medicine Mar, 2014 | Pubmed ID: 24450857
Clonal B-cell lymphocytosis: a new member?
Blood Feb, 2014 | Pubmed ID: 24558188
Heterogeneous functional effects of concomitant B cell receptor and TLR stimulation in chronic lymphocytic leukemia with mutated versus unmutated Ig genes.
Journal of immunology (Baltimore, Md. : 1950) May, 2014 | Pubmed ID: 24719462
The frequency of TP53 gene defects differs between chronic lymphocytic leukaemia subgroups harbouring distinct antigen receptors.
British journal of haematology Aug, 2014 | Pubmed ID: 24725250
SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.
Haematologica Aug, 2014 | Pubmed ID: 24859880
Management of chronic lymphocytic leukemia.
Haematologica Jun, 2014 | Pubmed ID: 24881042
Bendamustine and subcutaneous alemtuzumab combination is an effective treatment in relapsed/refractory chronic lymphocytic leukemia patients.
Haematologica Sep, 2014 | Pubmed ID: 24972768
Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy.
Blood Aug, 2014 | Pubmed ID: 25006127
Immunogenetic studies of chronic lymphocytic leukemia: revelations and speculations about ontogeny and clinical evolution.
Cancer research Aug, 2014 | Pubmed ID: 25074616
MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis.
Haematologica Aug, 2014 | Pubmed ID: 25082786
Ibrutinib: better combined with other drugs?
The Lancet. Oncology Sep, 2014 | Pubmed ID: 25150799
Toll-like receptor stimulation in splenic marginal zone lymphoma can modulate cell signaling, activation and proliferation.
Haematologica Nov, 2015 | Pubmed ID: 26294727
Targeting Hedgehog in haematological malignancies.
The Lancet. Haematology Aug, 2015 | Pubmed ID: 26688482
Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go?
Haematologica Mar, 2016 | Pubmed ID: 26928246
A new life for rituximab?
The Lancet. Haematology Mar, 2016 | Pubmed ID: 26947197
Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study.
The Lancet. Haematology Nov, 2014 | Pubmed ID: 27030157
Similar epidemiological trends of pre-neoplastic precursors and their respective lymphoid malignancies in Taiwan.
Annals of hematology Oct, 2016 | Pubmed ID: 27431581
Ibrutinib holds promise for patients with 17p deletion CLL.
The Lancet. Oncology 10, 2016 | Pubmed ID: 27637986
Ibrutinib in the real world patient: many lights and some shades.
Haematologica 12, 2016 | Pubmed ID: 27903711
Distinct molecular genetics of chronic lymphocytic leukemia in Taiwan: clinical and pathogenetic implications.
Haematologica Mar, 2017 | Pubmed ID: 28255015
Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification.
Haematologica 06, 2017 | Pubmed ID: 28566340
Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations.
Haematologica May, 2018 | Pubmed ID: 29449433
ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia-update on methodological approaches and results interpretation.
Leukemia May, 2018 | Pubmed ID: 29467486
Minimal residual disease analysis in chronic lymphocytic leukemia: a way for achieving more personalized treatments.
Leukemia Jun, 2018 | Pubmed ID: 29700386
Monoclonal B-cell lymphocytosis: Does the elderly patient need a specialistic approach?
European journal of internal medicine Sep, 2018 | Pubmed ID: 30268574
TP53 aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics.
Haematologica Nov, 2018 | Pubmed ID: 30442727
Andreas Agathangelidis*,1,
Lesley Ann Sutton*,2,3,
Anastasia Hadzidimitriou1,
Cristina Tresoldi4,
Anton W. Langerak5,
Chrysoula Belessi6,
Frederic Davi7,
Richard Rosenquist2,3,
Kostas Stamatopoulos1,2,
Paolo Ghia8
1Institute of Applied Biosciences, Centre for Research and Technology Hellas,
2Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University,
3Department of Molecular Medicine and Surgery, Karolinska Institutet,
4Division of Immunology, Transplantation and Infectious, IRCCS San Raffaele Scientific Institute,
5Department of Immunology, Laboratory for Medical Immunology, Erasmus University Medical Center,
6Hematology Department, Nikea General Hospital,
7, Assistance publique - Hôpitaux de Paris (AP-HP), Hopital Pitié-Salpêtrière, Department of Hematology, and UPMC University Paris 06, UMRS 1138,
8Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele and Università Vita-Salute San Raffaele
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