Leonard H. Augenlicht

Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate.

A gene expression profile that defines colon cell maturation in vitro.

Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention.

Short chain fatty acids and colon cancer.

Environment-gene interactions in intestinal cancer.

Microarray analysis in the clinical management of cancer.

Application of gene expression profiling to colon cell maturation, transformation and chemoprevention.

Gamma delta T cells provide an early source of interferon gamma in tumor immunity.

Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet.

TR3/Nur77 in colon cancer cell apoptosis.

The intrinsic mitochondrial membrane potential (Deltapsim) is associated with steady-state mitochondrial activity and the extent to which colonic epithelial cells undergo butyrate-mediated growth arrest and apoptosis.

Spontaneous aberrant crypt foci in Apc1638N mice with a mutant Apc allele.

Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin.

Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer.

Customizing chemotherapy for colon cancer: the potential of gene expression profiling.

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.

Methylation in the p21WAF1/cip1 promoter of Apc+/-, p21+/- mice and lack of response to sulindac.

Inactivation of p21WAF1/cip1 enhances intestinal tumor formation in Muc2-/- mice.

Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis.

p27kip1 in intestinal tumorigenesis and chemoprevention in the mouse.

The intrinsic mitochondrial membrane potential of colonic carcinoma cells is linked to the probability of tumor progression.

Pathways in nutritional modulation of homeostasis and tumorigenesis.

Kaiso-deficient mice show resistance to intestinal cancer.

Growth properties of colonic tumor cells are a function of the intrinsic mitochondrial membrane potential.

Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer.

Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT.

Interaction of genetic and dietary factors in mouse intestinal tumorigenesis.

JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo.

Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy.

c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression.

p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.

Sulindac suppresses beta-catenin expression in human cancer cells.

PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab.

Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer.

Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation.

Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors.

Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis.

HDAC4 promotes growth of colon cancer cells via repression of p21.

Proteomic changes during intestinal cell maturation in vivo.

Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer.

Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells.

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.

An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression.

Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors.

Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.

Altered dynamics of intestinal cell maturation in Apc1638N/+ mice.

Oxaliplatin resistance induced by ERCC1 up-regulation is abrogated by siRNA-mediated gene silencing in human colorectal cancer cells.

Prediction and testing of biological networks underlying intestinal cancer.

Transcriptional attenuation in colon carcinoma cells in response to butyrate.

MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells.

Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer.

Mybl2, downregulated during colon epithelial cell maturation, is suppressed by miR-365.

Stable differences in intrinsic mitochondrial membrane potential of tumor cell subpopulations reflect phenotypic heterogeneity.

Intestinal epithelial-specific PTEN inactivation results in tumor formation.

Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression.

Dietary cholecalciferol and calcium levels in a Western-style defined rodent diet alter energy metabolism and inflammatory responses in mice.

Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc(1638N/+) female mice.

The effect of lung cancer on cytokine expression in peripheral blood mononuclear cells.

Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.

Circulating soluble cytokine receptors and colorectal cancer risk.

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner.

Vitamin D is a Determinant of Mouse Intestinal Lgr5 Stem Cell Functions.