Martin Holcik

Distinct 5' UTRs regulate XIAP expression under normal growth conditions and during cellular stress.

Cloning and characterization of the rat homologues of the Inhibitor of Apoptosis protein 1, 2, and 3 genes.

Distinct expression of neuronal apoptosis inhibitory protein (NAIP) during murine development.

Drosophila veto puts a stop to cell survival.

The IAP proteins.

Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1.

The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.

Translational induction of the inhibitor of apoptosis protein HIAP2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element.

Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novel mechanism of tumor cell survival.

Translational upregulation of the X-linked inhibitor of apoptosis.

Targeting translation for treatment of cancer--a novel role for IRES?

Targeting endogenous inhibitors of apoptosis for treatment of cancer, stroke and multiple sclerosis.

Translational control in stress and apoptosis.

The utrophin A 5'-untranslated region confers internal ribosome entry site-mediated translational control during regeneration of skeletal muscle fibers.

Spurious splicing within the XIAP 5' UTR occurs in the Rluc/Fluc but not the betagal/CAT bicistronic reporter system.

Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival.

Internal ribosome entry site-mediated translation of Apaf-1, but not XIAP, is regulated during UV-induced cell death.

Distinct patterns of expression of the inhibitor of apoptosis protein cIAP2 during murine embryogenesis.

Searching for IRES.

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.

Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation.

Translation mechanism and regulation: old players, new concepts. Meeting on translational control and non-coding RNA.

A search for structurally similar cellular internal ribosome entry sites.

Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs.

RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha.

Cap-independent regulation of gene expression in apoptosis.

The eIF4G homolog DAP5/p97 supports the translation of select mRNAs during endoplasmic reticulum stress.

IRES-mediated translation of utrophin A is enhanced by glucocorticoid treatment in skeletal muscle cells.

Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins.

Strong eukaryotic IRESs have weak secondary structure.

RNA structure: new messages in translation, replication and disease. Workshop on the role of RNA structures in the translation of viral and cellular RNAs.

p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR.

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2.

eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress.

Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway.

IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress.

Tumor suppressor PDCD4 represses internal ribosome entry site-mediated translation of antiapoptotic proteins and is regulated by S6 kinase 2.

An oxygen-regulated switch in the protein synthesis machinery.

Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon.

A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression.

Celecoxib increases SMN and survival in a severe spinal muscular atrophy mouse model via p38 pathway activation.

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation.

Involvement of yeast HSP90 isoforms in response to stress and cell death induced by acetic acid.

Loss of cellular inhibitor of apoptosis protein 2 reduces atherosclerosis in atherogenic apoE-/- C57BL/6 mice on high-fat diet.

VPAC2 receptor agonist BAY 55-9837 increases SMN protein levels and moderates disease phenotype in severe spinal muscular atrophy mouse models.

Mutations in TRNT1, encoding the CCA-adding enzyme, cause congenital sideroblastic anemia with B cell immunodeficiency, periodic fevers and developmental delay (SIFD).

The role of IRES trans-acting factors in carcinogenesis.

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

HuR controls mitochondrial morphology through the regulation of BclxL translation.