Michael R. Holbrook

Crystallization and preliminary X-ray diffraction analysis of Langat virus envelope protein domain III.

Analysis of the complete genome of the tick-borne flavivirus Omsk hemorrhagic fever virus.

Molecular determinants of antigenicity of two subtypes of the tick-borne flavivirus Omsk haemorrhagic fever virus.

Use of a recombinant envelope protein subunit antigen for specific serological diagnosis of West Nile virus infection.

Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus.

1H, 13C and 15N resonance assignments for domain III of the West Nile virus envelope protein.

Solution structure and structural dynamics of envelope protein domain III of mosquito- and tick-borne flaviviruses.

Use of recombinant E protein domain III-based enzyme-linked immunosorbent assays for differentiation of tick-borne encephalitis serocomplex flaviviruses from mosquito-borne flaviviruses.

An animal model for the tickborne flavivirus--Omsk hemorrhagic fever virus.

Yellow fever virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and induce novel changes in gene expression.

Structure of the envelope protein domain III of Omsk hemorrhagic fever virus.

Animal models of highly pathogenic RNA viral infections: encephalitis viruses.

Animal models of highly pathogenic RNA viral infections: hemorrhagic fever viruses.

Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).

Three-dimensional organization of Rift Valley fever virus revealed by cryoelectron tomography.

Phosphoinositide-3 kinase-Akt pathway controls cellular entry of Ebola virus.

Sub-genomic replicon and virus-like particles of Omsk hemorrhagic fever virus.

Single-particle cryo-electron microscopy of Rift Valley fever virus.

Clinical evaluation of highly pathogenic tick-borne flavivirus infection in the mouse model.

Potential impact of a 2-person security rule on BioSafety Level 4 laboratory workers.

A catalytically and genetically optimized beta-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics.

A complex adenovirus-vectored vaccine against Rift Valley fever virus protects mice against lethal infection in the presence of preexisting vector immunity.

Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection.

A replication-incompetent Rift Valley fever vaccine: chimeric virus-like particles protect mice and rats against lethal challenge.

The NS5 protein of the virulent West Nile virus NY99 strain is a potent antagonist of type I interferon-mediated JAK-STAT signaling.

A broad-spectrum antiviral targeting entry of enveloped viruses.

gammadelta T cells promote the maturation of dendritic cells during West Nile virus infection.

VIPR: A probabilistic algorithm for analysis of microbial detection microarrays.

Novel suspension cell-based vaccine production systems for Rift Valley fever virus-like particles.

Construction of an infectious cDNA clone for Omsk hemorrhagic fever virus, and characterization of mutations in NS2A and NS5.

Comparative analysis of immune responses to Russian spring-summer encephalitis and Omsk hemorrhagic fever viruses in mouse models.

Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening.

A proposal to change existing virus species names to non-Latinized binomials.

Antiviral activities of ISG20 in positive-strand RNA virus infections.

Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding.

T-705 (favipiravir) inhibition of arenavirus replication in cell culture.

Differential cytokine responses from primary human Kupffer cells following infection with wild-type or vaccine strain yellow fever virus.

Infection of hepatocytes with 17-D vaccine-strain yellow fever virus induces a strong pro-inflammatory host response.

Inactivated or live-attenuated bivalent vaccines that confer protection against rabies and Ebola viruses.

Recombinant Rift Valley fever vaccines induce protective levels of antibody in baboons and resistance to lethal challenge in mice.

Chemotactic and inflammatory responses in the liver and brain are associated with pathogenesis of Rift Valley fever virus infection in the mouse.

An assembly model of rift valley Fever virus.

Kyasanur forest disease.

Japanese Encephalitis Vaccines.

Release of dengue virus genome induced by a peptide inhibitor.

Coagulation factors, fibrinogen and plasminogen activator inhibitor-1, are differentially regulated by yellow fever virus infection of hepatocytes.

Tick-borne Encephalitis Vaccines.

Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays.

A critical determinant of neurological disease associated with highly pathogenic tick-borne flavivirus in mice.

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection.

Comparative pathogenesis of Alkhumra hemorrhagic fever and Kyasanur forest disease viruses in a mouse model.

Animal models of viral hemorrhagic fever.

Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis.

Cytokine response in mouse bone marrow derived macrophages after infection with pathogenic and non-pathogenic Rift Valley fever virus.

Possible sexual transmission of Ebola virus - Liberia, 2015.

Inactivation and safety testing of Middle East Respiratory Syndrome Coronavirus.

Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease.

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012.

Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo.

Characterization of Yellow Fever Virus Infection of Human and Non-human Primate Antigen Presenting Cells and Their Interaction with CD4+ T Cells.