Diabetes Center
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The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance.
European journal of immunology Apr, 2002 | Pubmed ID: 11920563
The Src family kinase Fyn mediates signals induced by TCR antagonists.
Journal of immunology (Baltimore, Md. : 1950) May, 2002 | Pubmed ID: 11970992
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.
The New England journal of medicine May, 2002 | Pubmed ID: 12037148
Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2002 | Pubmed ID: 12097362
The immune tolerance network: a new paradigm for developing tolerance-inducing therapies.
The Journal of allergy and clinical immunology Jul, 2002 | Pubmed ID: 12110811
Inability to induce tolerance through direct antigen presentation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Jul, 2002 | Pubmed ID: 12118894
Immunotherapy of insulin-dependent diabetes mellitus.
Current opinion in immunology Oct, 2002 | Pubmed ID: 12183168
Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial.
The Journal of rheumatology Sep, 2002 | Pubmed ID: 12233885
When ligand becomes receptor--tolerance via B7 signaling on DCs.
Nature immunology Nov, 2002 | Pubmed ID: 12407416
Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.
The Journal of experimental medicine Jan, 2003 | Pubmed ID: 12515820
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Nature immunology Feb, 2003 | Pubmed ID: 12524538
Impairment of NK cell function by NKG2D modulation in NOD mice.
Immunity Jan, 2003 | Pubmed ID: 12530974
CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2003 | Pubmed ID: 12538715
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).
The Journal of clinical investigation Feb, 2003 | Pubmed ID: 12569167
Natural versus adaptive regulatory T cells.
Nature reviews. Immunology Mar, 2003 | Pubmed ID: 12658273
Directed evolution of a single-chain class II MHC product by yeast display.
Protein engineering Feb, 2003 | Pubmed ID: 12676983
Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis.
The Journal of clinical investigation Jun, 2003 | Pubmed ID: 12813028
Clinical trials of transplant tolerance: slow but steady progress.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Jul, 2003 | Pubmed ID: 12814471
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.
Nature medicine Sep, 2003 | Pubmed ID: 12937416
Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2003 | Pubmed ID: 14500627
Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2003 | Pubmed ID: 14607967
The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.
Novartis Foundation symposium , 2003 | Pubmed ID: 14609212
CTLA-4 and tolerance: the biochemical point of view.
Immunologic research , 2003 | Pubmed ID: 14713717
Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2004 | Pubmed ID: 14734721
Beta-cell replacement for type I diabetes.
Annual review of medicine , 2004 | Pubmed ID: 14746513
Transplantation of cultured islets from two-layer preserved pancreases in type 1 diabetes with anti-CD3 antibody.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Mar, 2004 | Pubmed ID: 14961992
CTLA-4: acting at the synapse.
Molecular interventions Jul, 2002 | Pubmed ID: 14993389
Notch 1 signaling regulates peripheral T cell activation.
Immunity Apr, 2004 | Pubmed ID: 15084270
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
The Journal of experimental medicine Jun, 2004 | Pubmed ID: 15184499
CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2004 | Pubmed ID: 15187122
NKG2D blockade prevents autoimmune diabetes in NOD mice.
Immunity Jun, 2004 | Pubmed ID: 15189740
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2004 | Pubmed ID: 15322272
Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes.
Clinical immunology (Orlando, Fla.) Oct, 2004 | Pubmed ID: 15380527
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.
The Journal of clinical investigation Oct, 2004 | Pubmed ID: 15467837
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
European journal of immunology Nov, 2004 | Pubmed ID: 15468055
CTLA-4Ig is finally making it: a personal perspective.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Mar, 2005 | Pubmed ID: 15707394
The NOD mouse: a model of immune dysregulation.
Annual review of immunology , 2005 | Pubmed ID: 15771578
Regulatory T-cell therapy: is it ready for the clinic?
Nature reviews. Immunology Apr, 2005 | Pubmed ID: 15775994
Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2005 | Pubmed ID: 15814673
Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2005 | Pubmed ID: 15814694
An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice.
Journal of immunology (Baltimore, Md. : 1950) May, 2005 | Pubmed ID: 15843526
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.
Diabetes Jun, 2005 | Pubmed ID: 15919798
B7-independent inhibition of T cells by CTLA-4.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2005 | Pubmed ID: 15972645
A comprehensive review of interventions in the NOD mouse and implications for translation.
Immunity Aug, 2005 | Pubmed ID: 16111631
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2005 | Pubmed ID: 16116193
A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2005 | Pubmed ID: 16148106
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.
The Journal of clinical investigation Oct, 2005 | Pubmed ID: 16167085
How do CD4+CD25+ regulatory T cells control autoimmunity?
Current opinion in immunology Dec, 2005 | Pubmed ID: 16209918
Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2005 | Pubmed ID: 16237054
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
The Journal of experimental medicine Nov, 2005 | Pubmed ID: 16287710
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Nature immunology Jan, 2006 | Pubmed ID: 16311599
Achieving antigen-specific tolerance in diabetes: regulating specifically.
International reviews of immunology Sep-Dec, 2005 | Pubmed ID: 16318983
Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential.
Seminars in immunology Apr, 2006 | Pubmed ID: 16458533
CTLA4Ig: bridging the basic immunology with clinical application.
Immunity Mar, 2006 | Pubmed ID: 16546089
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.
The Journal of clinical investigation May, 2006 | Pubmed ID: 16628253
Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship?
Nature immunology Jun, 2006 | Pubmed ID: 16715063
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.
The Journal of experimental medicine Jul, 2006 | Pubmed ID: 16818678
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2006 | Pubmed ID: 16849451
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
The Journal of clinical investigation Aug, 2006 | Pubmed ID: 16886063
Regulatory T-cell physiology and application to treat autoimmunity.
Immunological reviews Aug, 2006 | Pubmed ID: 16903917
Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.
Diabetes Sep, 2006 | Pubmed ID: 16936208
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
The Journal of experimental medicine Nov, 2006 | Pubmed ID: 17116737
Sensory neurons link the nervous system and autoimmune diabetes.
Cell Dec, 2006 | Pubmed ID: 17174888
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2007 | Pubmed ID: 17389382
Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.
European journal of immunology May, 2007 | Pubmed ID: 17429849
Differential roles of costimulatory signaling pathways in type 1 diabetes mellitus.
The review of diabetic studies : RDS , 2004 | Pubmed ID: 17491700
Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2007 | Pubmed ID: 17617592
Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Clinical immunology (Orlando, Fla.) Oct, 2007 | Pubmed ID: 17627890
CD3-specific antibodies: a portal to the treatment of autoimmunity.
Nature reviews. Immunology Aug, 2007 | Pubmed ID: 17641665
What does the future hold for cell-based tolerogenic therapy?
Nature reviews. Immunology Aug, 2007 | Pubmed ID: 17653127
Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.
Endocrinology Nov, 2007 | Pubmed ID: 17673522
对树突状细胞整合素 α (v) beta8 损失导致小鼠自身免疫和结肠炎。
Nature Sep, 2007 | Pubmed ID: 17694047
B cell depletion: a novel therapy for autoimmune diabetes?
The Journal of clinical investigation Dec, 2007 | Pubmed ID: 18060022
Regulated beta-cell regeneration in the adult mouse pancreas.
Diabetes Apr, 2008 | Pubmed ID: 18083786
Safer, longer-lasting regulatory T cells with beta-catenin.
Nature medicine Feb, 2008 | Pubmed ID: 18256611
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation.
Nature immunology Mar, 2008 | Pubmed ID: 18285775
CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.
Nature medicine May, 2008 | Pubmed ID: 18438416
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.
Immunity May, 2008 | Pubmed ID: 18468463
Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2008 | Pubmed ID: 18523243
Human regulatory T cells: role in autoimmune disease and therapeutic opportunities.
Immunological reviews Jun, 2008 | Pubmed ID: 18613848
T regulatory cells in autoimmune diabetes: past challenges, future prospects.
Journal of clinical immunology Nov, 2008 | Pubmed ID: 18716861
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.
The Journal of experimental medicine Sep, 2008 | Pubmed ID: 18725525
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.
Immunological reviews Aug, 2008 | Pubmed ID: 18759926
Innate immunity and intestinal microbiota in the development of Type 1 diabetes.
Nature Oct, 2008 | Pubmed ID: 18806780
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2008 | Pubmed ID: 19015530
Expansion of human regulatory T-cells from patients with type 1 diabetes.
Diabetes Mar, 2009 | Pubmed ID: 19074986
The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients.
Clinical immunology (Orlando, Fla.) Apr, 2009 | Pubmed ID: 19150256
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.
The Journal of experimental medicine Mar, 2009 | Pubmed ID: 19221395
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.
Immunological reviews May, 2009 | Pubmed ID: 19426214
Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.
Clinical immunology (Orlando, Fla.) Aug, 2009 | Pubmed ID: 19443276
Plasticity of CD4(+) FoxP3(+) T cells.
Current opinion in immunology Jun, 2009 | Pubmed ID: 19500966
T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2009 | Pubmed ID: 19535634
Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2009 | Pubmed ID: 19561097
Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice.
Endocrinology Oct, 2009 | Pubmed ID: 19574401
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.
Nature immunology Sep, 2009 | Pubmed ID: 19633673
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.
Nature immunology Nov, 2009 | Pubmed ID: 19783989
Regulatory T cells as therapeutic targets in rheumatoid arthritis.
Nature reviews. Rheumatology Oct, 2009 | Pubmed ID: 19798031
The functional plasticity of T cell subsets.
Nature reviews. Immunology Nov, 2009 | Pubmed ID: 19809471
Is antigen specificity of autoreactive T cells the key to islet entry?
Immunity Oct, 2009 | Pubmed ID: 19833083
Autoimmunity.
Current opinion in immunology Dec, 2009 | Pubmed ID: 19879742
Regulatory T cells directed to the site of the action.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2009 | Pubmed ID: 19955436
Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs.
Diabetes Jun, 2010 | Pubmed ID: 20299465
Ten years of the Immune Tolerance Network: an integrated clinical research organization.
Science translational medicine Feb, 2010 | Pubmed ID: 20371484
Small RNA regulators of T cell-mediated autoimmunity.
Journal of clinical immunology May, 2010 | Pubmed ID: 20393792
Suppression of human anti-porcine natural killer cell xenogeneic responses by combinations of monoclonal antibodies specific to CD2 and NKG2D and extracellular signal-regulated kinase kinase inhibitor.
Immunology Aug, 2010 | Pubmed ID: 20406306
Genetics, pathogenesis and clinical interventions in type 1 diabetes.
Nature Apr, 2010 | Pubmed ID: 20432533
Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia.
Current opinion in organ transplantation Aug, 2010 | Pubmed ID: 20631613
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
PloS one , 2010 | Pubmed ID: 20668510
FK506 causes cellular and functional defects in human natural killer cells.
Journal of leukocyte biology Dec, 2010 | Pubmed ID: 20671192
Clusterin synergizes with IL-2 for the expansion and IFN-γ production of natural killer cells.
Journal of leukocyte biology Nov, 2010 | Pubmed ID: 20729304
The Immune Tolerance Network at 10 years: tolerance research at the bedside.
Nature reviews. Immunology Nov, 2010 | Pubmed ID: 20972473
Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.
Transplantation Dec, 2010 | Pubmed ID: 20978464
Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.
The Journal of clinical investigation Dec, 2010 | Pubmed ID: 21099117
Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells.
PloS one , 2011 | Pubmed ID: 21253593
Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2011 | Pubmed ID: 21357258
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2011 | Pubmed ID: 21368230
Mechanisms of tolerance.
Immunological reviews May, 2011 | Pubmed ID: 21488886
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Immunological reviews May, 2011 | Pubmed ID: 21488898
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited.
Diabetes May, 2011 | Pubmed ID: 21525508
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.
The Journal of surgical research Jul, 2011 | Pubmed ID: 21571317
Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2011 | Pubmed ID: 21613616
Regulatory T cells: stability revisited.
Trends in immunology Jul, 2011 | Pubmed ID: 21620768
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2011 | Pubmed ID: 21742976
Control of TH17 cells occurs in the small intestine.
Nature Jul, 2011 | Pubmed ID: 21765430
Type 1 diabetes immunotherapy: is the glass half empty or half full?
Science translational medicine Aug, 2011 | Pubmed ID: 21832236
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.
Nature immunology Sep, 2011 | Pubmed ID: 21841785
Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2011 | Pubmed ID: 21934098
A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2011 | Pubmed ID: 21967896
The yin and yang of interleukin-2-mediated immunotherapy.
The New England journal of medicine Dec, 2011 | Pubmed ID: 22129258
CD4+Foxp3+ regulatory T cell therapy in transplantation.
Journal of molecular cell biology Feb, 2012 | Pubmed ID: 22170955
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