F. Edward Dudek

Absence of temporal lobe epilepsy pathology in dogs with medically intractable epilepsy.

Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy.

Episodic bursting activity and response to excitatory amino acids in acutely dissociated gonadotropin-releasing hormone neurons genetically targeted with green fluorescent protein.

The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus.

Reassessment of the effects of cycloheximide on mossy fiber sprouting and epileptogenesis in the pilocarpine model of temporal lobe epilepsy.

The search for animal models of epileptogenesis and pharmacoresistance: are there biologic barriers to simple validation strategies?

Effects of fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine-induced epilepsy.

GABA receptor-mediated inhibition of neuronal activity in rat SCN in vitro: pharmacology and influence of circadian phase.

Riluzole-sensitive slowly inactivating sodium current in rat suprachiasmatic nucleus neurons.

Mechanism of irregular firing of suprachiasmatic nucleus neurons in rat hypothalamic slices.

Increased excitatory synaptic activity and local connectivity of hippocampal CA1 pyramidal cells in rats with kainate-induced epilepsy.

Cortical Dysplasia and Epileptogenesis: Models and Mechanisms.

New Evidence for an Important Role of Endogenous GABA in Seizure Generation in the Immature Hippocampus.

High-frequency Oscillations and Neocortical Seizures: Do They Have a Role in Seizure Onset, and Which Mechanisms Generate Them?

Single-gene Mutation Leads to Localized Disruption of Cortical Interneuron Development and Increased Seizure Susceptibility.

Does Neuroprotection Prevent Epileptogenesis?

Synaptic Reorganization in an Experimental Model of Posttraumatic Epilepsy.

The Epileptic Neuron Redux.

Gap Junctions and Fast Oscillations: A Role in Seizures and Epileptogenesis?

Role of Glial Cells in Seizures and Epilepsy: Intracellular Calcium Oscillations sn Spatial Buffering.

Selective Inhibitory Interneuron Loss Produces Chronic Hippocampal Hyperexcitability.

Neuropeptide Y May Be an Endogenous Anticonvulsant in Hippocampus.

Zinc and Epileptogenesis.

GluR5 Kainate Receptors and Topiramate: A New Site of Action for Antiepileptic Drugs?

Does Hippocampal Neurogenesis after Kainate-induced Apoptosis In Neonatal Rats Replace Lost Neurons?

Epilepsy and synaptic reorganization in a perinatal rat model of hypoxia-ischemia.

Hyperpolarization-activated Cation Channels in Human and Experimental Epilepsy: Do They Play a Role in Epileptogenesis?

Update on connexins and gap junctions in neurons and glia in the mammalian nervous system.

Electrophysiological evidence using focal flash photolysis of caged glutamate that CA1 pyramidal cells receive excitatory synaptic input from the subiculum.

Use of chronic epilepsy models in antiepileptic drug discovery: the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy.

5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus.

Changes in mIPSCs and sIPSCs after kainate treatment: evidence for loss of inhibitory input to dentate granule cells and possible compensatory responses.

Loss of GABAergic Interneurons in Seizure-induced Epileptogenesis.

Noise of the slowly inactivating Na current in suprachiasmatic nucleus neurons.

Detection of increased local excitatory circuits in the hippocampus during epileptogenesis using focal flash photolysis of caged glutamate.

Seizure-induced neurogenesis and epilepsy: involvement of ectopic granule cells?

The epileptic GABA(A) receptor: a target for epileptogenesis and for new AEDs?

Mossy fiber sprouting and recurrent excitation: direct electrophysiologic evidence and potential implications.

Is there a "critical period" for intervention in posttraumatic epilepsy?

Do interictal spikes drive epileptogenesis?

Regulation of brain water: is there a role for aquaporins in epilepsy?

Are altered excitatory synapses found in neuronal migration disorders?

Efficient unsupervised algorithms for the detection of seizures in continuous EEG recordings from rats after brain injury.

Chronic cortical injury and epileptogensis: a possible role for intracellular chloride homeostasis.

The hyperinhibition hypothesis in epileptogenesis: an assessment of the evidence.

Epilepsy and reproductive disorders: the role of the gonadotropin-releasing hormone network.

The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy.

Activation of Fos during spontaneous hippocampal seizures in a model of temporal lobe epilepsy.

Changes in mIPSCs and sIPSCs after kainate treatment: status epilepticus-induced neuronal loss or direct activation of kainate receptors?

How independent are initiation, propagation, and termination of epileptiform activity?

Single-neuron activity and imaging during epileptogenesis: what can be seen and how best to see it?

Interictal spikes and epileptogenesis.

Laser scanning photostimulation: new evidence for enhanced recurrent excitation in a model of posttraumatic epilepsy.

How does the balance of excitation and inhibition shift during epileptogenesis?

Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: comparison of intraperitoneal injections with drug-in-food protocols.

Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system.

Epileptogenesis in the dentate gyrus: a critical perspective.

Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis.

Neuropathogical features of a rat model for perinatal hypoxic-ischemic encephalopathy with associated epilepsy.

Calcium currents burst back: a possible role for dendrites in epileptogenesis.

Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling versus Status Epilepticus Models.

Circadian difference in firing rate of isolated rat suprachiasmatic nucleus neurons.

Chemoconvulsant model of chronic spontaneous seizures.

In search of a new and improved target for antiepileptic drugs: sialic acid?

A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy.

On the role of calcium and potassium currents in circadian modulation of firing rate in rat suprachiasmatic nucleus neurons: multielectrode dish analysis.

NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy.

Single and repetitive paired-pulse suppression: a parametric analysis and assessment of usefulness in epilepsy research.

Development of spontaneous recurrent seizures after kainate-induced status epilepticus.

Commentary: a skeptical view of experimental gene therapy to block epileptogenesis.

Is modulation of cortical synapses after brain trauma homeostatic? Or, since when is epilepsy normal?

Microseizures in human neocortex: a role for ultra-small seizures?

EEG spike activity precedes epilepsy after kainate-induced status epilepticus.

Both synaptic and intrinsic mechanisms underlie the different properties of population bursts in the hippocampal CA3 area of immature versus adult rats.

Epileptogenesis: a new twist on the balance of excitation and inhibition.

Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy.

The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat.

Counterpoint to "what is an epileptic seizure?" by D'Ambrosio and Miller.

Is neuronal death necessary for acquired epileptogenesis in the immature brain?

Primary and secondary mechanisms of epileptogenesis in the temporal lobe: there is a before and an after.

Axon sprouting and synaptic reorganization of GABAergic interneurons: a focused look at a general question.

Repetitive perforant-path stimulation induces epileptiform bursts in minislices of dentate gyrus from rats with kainate-induced epilepsy.

Interictal spikes: harbingers or causes of epilepsy?

The time course of acquired epilepsy: implications for therapeutic intervention to suppress epileptogenesis.

A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models.

Seizure probability in animal models of acquired epilepsy: a perspective on the concept of the preictal state.

Mechanisms of Seizure-Induced Inflammation of the Brain: Many Possible Roles for Neuronal COX-2.

Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design.

Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation.

Epilepsy therapy development: technical and methodologic issues in studies with animal models.

Issues related to development of antiepileptogenic therapies.

Epilepsy biomarkers.

Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus.

When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?

Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy.