Francois Paquet-Durand

PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.

Turning teratocarcinoma cells into neurons: rapid differentiation of NT-2 cells in floating spheres.

Hypoxic/ischaemic cell damage in cultured human NT-2 neurons.

Differential modification of phosducin protein in degenerating rd1 retina is associated with constitutively active Ca2+/calmodulin kinase II in rod outer segments.

Calpain is activated in degenerating photoreceptors in the rd1 mouse.

Up-regulation and increased phosphorylation of protein kinase C (PKC) delta, mu and theta in the degenerating rd1 mouse retina.

Diltiazem protects human NT-2 neurons against excitotoxic damage in a model of simulated ischemia.

CNTF+BDNF treatment and neuroprotective pathways in the rd1 mouse retina.

Calpain activity in retinal degeneration.

Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse.

Human model neurons in studies of brain cell damage and neural repair.

Photoreceptor cell death mechanisms in inherited retinal degeneration.

PKG activity causes photoreceptor cell death in two retinitis pigmentosa models.

Cellular phenotypes of human model neurons (NT2) after differentiation in aggregate culture.

Study of gene-targeted mouse models of splicing factor gene Prpf31 implicated in human autosomal dominant retinitis pigmentosa (RP).

Spectral domain optical coherence tomography in mouse models of retinal degeneration.

Simulation of stroke-related damage in cultured human nerve cells.

cGMP-dependent cone photoreceptor degeneration in the cpfl1 mouse retina.

Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function.

Photoreceptor rescue and toxicity induced by different calpain inhibitors.

A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa.

Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats.

HDAC inhibition prevents Rd1 mouse photoreceptor degeneration.

In vivo assessment of rodent retinal structure using spectral domain optical coherence tomography.

cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function.

Light-driven calcium signals in mouse cone photoreceptors.

Calpain mediated ataxin-3 cleavage in the molecular pathogenesis of Spinocerebellar Ataxia Type 3 (SCA3).

Testing for a gap junction-mediated bystander effect in retinitis pigmentosa: secondary cone death is not altered by deletion of connexin36 from cones.

Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors.

Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina.

Expression of poly(ADP-ribose) glycohydrolase in wild-type and PARG-110 knock-out retina.

Characterization of a mouse model with complete RPE loss and its use for RPE cell transplantation.

Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration.

Targeted Ablation of the Pde6h Gene in Mice Reveals Cross-species Differences in Cone and Rod Phototransduction Protein Isoform Inventory.