Tumour Angiogenesis Program
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Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo.
Blood Jun, 2002 | Pubmed ID: 12036873
The role of tumor lymphangiogenesis in metastatic spread.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jul, 2002 | Pubmed ID: 12087053
The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer.
Growth factors (Chur, Switzerland) Jun, 2002 | Pubmed ID: 12148568
Lymphangiogenesis and cancer metastasis.
Nature reviews. Cancer Aug, 2002 | Pubmed ID: 12154350
Molecular control of lymphangiogenesis.
BioEssays : news and reviews in molecular, cellular and developmental biology Nov, 2002 | Pubmed ID: 12386934
Regenerating lizard tails: a new model for investigating lymphangiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2003 | Pubmed ID: 12514111
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.
Circulation research May, 2003 | Pubmed ID: 12714562
Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens.
The Journal of biological chemistry Sep, 2003 | Pubmed ID: 12867434
Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.
The Journal of experimental medicine Sep, 2003 | Pubmed ID: 12963694
Vascular endothelial growth factor-D expression in human atherosclerotic lesions.
Cardiovascular research Oct, 2003 | Pubmed ID: 14553837
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue.
Human gene therapy Oct, 2003 | Pubmed ID: 14577925
Adenoviral catheter-mediated intramyocardial gene transfer using the mature form of vascular endothelial growth factor-D induces transmural angiogenesis in porcine heart.
Circulation Mar, 2004 | Pubmed ID: 14967735
Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2004 | Pubmed ID: 15297417
Molecular regulation of the VEGF family -- inducers of angiogenesis and lymphangiogenesis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Jul-Aug, 2004 | Pubmed ID: 15563310
Lymphangiogenic growth factors as markers of tumor metastasis.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Jul-Aug, 2004 | Pubmed ID: 15563315
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
The Journal of clinical investigation Feb, 2005 | Pubmed ID: 15668734
Focus on lymphangiogenesis in tumor metastasis.
Cancer cell Feb, 2005 | Pubmed ID: 15710325
Vascular endothelial growth factor D is dispensable for development of the lymphatic system.
Molecular and cellular biology Mar, 2005 | Pubmed ID: 15743836
Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer.
International journal of oncology Sep, 2005 | Pubmed ID: 16077915
Lymphatic endothelium: an important interactive surface for malignant cells.
Pulmonary pharmacology & therapeutics , 2006 | Pubmed ID: 16286238
A Simple and Rapid Method for Genetic Transformation of Lactic Streptococci by Electroporation.
Applied and environmental microbiology Mar, 1988 | Pubmed ID: 16347576
Mechanisms of lymphangiogenesis: targets for blocking the metastatic spread of cancer.
Current cancer drug targets Dec, 2005 | Pubmed ID: 16375662
Tumor lymphangiogenesis and metastatic spread-new players begin to emerge.
International journal of cancer Oct, 2006 | Pubmed ID: 16557570
Lymphatic vessels in cancer metastasis: bridging the gaps.
Carcinogenesis Sep, 2006 | Pubmed ID: 16597644
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.
The American journal of pathology Aug, 2006 | Pubmed ID: 16877368
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2007 | Pubmed ID: 17242158
Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis.
The American journal of pathology Apr, 2007 | Pubmed ID: 17392173
Molecular pathways for lymphangiogenesis and their role in human disease.
Novartis Foundation symposium , 2007 | Pubmed ID: 17534064
A system for quantifying the patterning of the lymphatic vasculature.
Growth factors (Chur, Switzerland) Dec, 2007 | Pubmed ID: 18365872
Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.
Molecular and cellular biology Aug, 2008 | Pubmed ID: 18519586
Molecular control of lymphatic metastasis.
Annals of the New York Academy of Sciences , 2008 | Pubmed ID: 18519975
Targeting tumor stroma.
Current cancer drug targets Sep, 2008 | Pubmed ID: 18781890
Sox18 induces development of the lymphatic vasculature in mice.
Nature Dec, 2008 | Pubmed ID: 18931657
From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in cancer therapy.
Lymphatic research and biology , 2008 | Pubmed ID: 19093789
Vascular endothelial growth factor-D over-expressing tumor cells induce differential effects on uterine vasculature in a mouse model of endometrial cancer.
Reproductive biology and endocrinology : RB&E , 2010 | Pubmed ID: 20615255
Targeting lymphatic vessel functions through tyrosine kinases.
Journal of angiogenesis research , 2010 | Pubmed ID: 20698997
The VD1 neutralizing antibody to vascular endothelial growth factor-D: binding epitope and relationship to receptor binding.
Journal of molecular biology Apr, 2011 | Pubmed ID: 21315726
Proteolytic processing of vascular endothelial growth factor-D is essential for its capacity to promote the growth and spread of cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug, 2011 | Pubmed ID: 21515745
A role for bone morphogenetic protein-4 in lymph node vascular remodeling and primary tumor growth.
Cancer research Oct, 2011 | Pubmed ID: 21868759
Preparation of human vascular endothelial growth factor-D for structural and preclinical therapeutic studies.
Protein expression and purification Mar, 2012 | Pubmed ID: 22261343
VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium.
Cancer cell Feb, 2012 | Pubmed ID: 22340592
Lymphatic vessel density in primary melanomas predicts sentinel lymph node status and risk of metastasis.
Histopathology Oct, 2012 | Pubmed ID: 22734806
Vascular endothelial growth factor-D: signaling mechanisms, biology, and clinical relevance.
Growth factors (Chur, Switzerland) Oct, 2012 | Pubmed ID: 22817635
Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
The American journal of pathology Dec, 2012 | Pubmed ID: 23063660
The connection between lymphangiogenic signalling and prostaglandin biology: a missing link in the metastatic pathway.
Oncotarget Aug, 2012 | Pubmed ID: 23097685
Tumor location and nature of lymphatic vessels are key determinants of cancer metastasis.
Clinical & experimental metastasis Mar, 2013 | Pubmed ID: 23124573
The propeptides of VEGF-D determine heparin binding, receptor heterodimerization, and effects on tumor biology.
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23404505
The VEGF signaling pathway in cancer: the road ahead.
Chinese journal of cancer Jun, 2013 | Pubmed ID: 23419196
Vascular endothelial growth factor-d modulates caliber and function of initial lymphatics in the dermis.
The Journal of investigative dermatology Aug, 2013 | Pubmed ID: 23439394
Signaling for lymphangiogenesis via VEGFR-3 is required for the early events of metastasis.
Clinical & experimental metastasis Aug, 2013 | Pubmed ID: 23591595
Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2014 | Pubmed ID: 24048441
Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development.
Human molecular genetics Mar, 2014 | Pubmed ID: 24163130
Lymphovascular and neural regulation of metastasis: shared tumour signalling pathways and novel therapeutic approaches.
Best practice & research. Clinical anaesthesiology Dec, 2013 | Pubmed ID: 24267548
VEGFD regulates blood vascular development by modulating SOX18 activity.
Blood Feb, 2014 | Pubmed ID: 24269955
The proteolytic activation of angiogenic and lymphangiogenic growth factors in cancer--its potential relevance for therapeutics and diagnostics.
Current medicinal chemistry , 2014 | Pubmed ID: 24350854
Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis.
Development (Cambridge, England) Mar, 2014 | Pubmed ID: 24523457
Lymphangiogenesis and lymphatic vessel remodelling in cancer.
Nature reviews. Cancer Mar, 2014 | Pubmed ID: 24561443
Exploring the role of endothelium in the tumour response to anti-angiogenic therapy.
Biochemical Society transactions Dec, 2014 | Pubmed ID: 25399572
Vegf-d promotes pulmonary oedema in hyperoxic acute lung injury.
The Journal of pathology Feb, 2016 | Pubmed ID: 26924464
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