Louis H. Philipson

TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells.

Insulin secretory deficiency and glucose intolerance in Rab3A null mice.

Visualizing superoxide production in normal and diabetic rat islets of Langerhans.

Modeling of Ca2+ flux in pancreatic beta-cells: role of the plasma membrane and intracellular stores.

Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses.

Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.

Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?

FRET-based voltage probes for confocal imaging: membrane potential oscillations throughout pancreatic islets.

5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.

Adenine nucleotide regulation in pancreatic beta-cells: modeling of ATP/ADP-Ca2+ interactions.

Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modeling.

Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.

Oxidative reactive species in cell injury: Mechanisms in diabetes mellitus and therapeutic approaches.

Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.

Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression.

Functional MR microimaging of pancreatic beta-cell activation.

Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy.

Cold climate genes and the prevalence of type 2 diabetes mellitus.

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.

Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate.

Protective role for nitric oxide during the endoplasmic reticulum stress response in pancreatic beta-cells.

Ethics of hematopoietic stem cell transplantation in type 1 diabetes mellitus.

Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion.

Insulin gene mutations as a cause of permanent neonatal diabetes.

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta in pancreatic beta-cells and in iPLA2beta-null mice.

Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach.

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

Reactive species, cellular repair and risk factors in the onset of type 2 diabetes mellitus: review and hypothesis.

When BAD is good for beta cells.

Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells.

Diagnosis and treatment of neonatal diabetes: a United States experience.

The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution.

The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing.

Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice.

Tooth discoloration in patients with neonatal diabetes after transfer onto glibenclamide: a previously unreported side effect.

A nanoporous, transparent microcontainer for encapsulated islet therapy.

The granular chloride channel ClC-3 is permissive for insulin secretion.

In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.

Update in neonatal diabetes.

Neonatal diabetes mellitus: a model for personalized medicine.

Glucose sensing in the pancreatic beta cell: a computational systems analysis.

Blood sugar measurement in zebrafish reveals dynamics of glucose homeostasis.

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.

Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses.

Glucose-induced ERM protein activation and translocation regulates insulin secretion.

Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.

The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetes.

Erratum to: Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.

Who should have genetic testing for maturity-onset diabetes of the young?

Creation of the Web-based University of Chicago Monogenic Diabetes Registry: using technology to facilitate longitudinal study of rare subtypes of diabetes.

Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis.

Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment.

SUMO down-regulates GLP-1 stimulated cAMP generation and insulin secretion.