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Department of Molecular and Cellular Biology
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A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function.
Molecular and cellular biology Apr, 2003 | Pubmed ID: 12665569
Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.
Nature biotechnology May, 2003 | Pubmed ID: 12679785
Angiogenic actions of angiopoietin-1 require endothelium-derived nitric oxide.
The American journal of pathology Jun, 2003 | Pubmed ID: 12759249
Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2004 | Pubmed ID: 15067126
A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.
The American journal of pathology Mar, 2005 | Pubmed ID: 15743796
Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis.
Molecular and cellular biology Jun, 2005 | Pubmed ID: 15899871
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.
Nature Apr, 2006 | Pubmed ID: 16525419
Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays.
Molecular and cellular biology Nov, 2006 | Pubmed ID: 16982700
Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Molecular and cellular biology Jul, 2007 | Pubmed ID: 17452444
Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization.
Molecular and cellular biology Mar, 2008 | Pubmed ID: 18212058
Nck proteins maintain the adult glomerular filtration barrier.
Journal of the American Society of Nephrology : JASN Jul, 2009 | Pubmed ID: 19443634
Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development.
Developmental dynamics : an official publication of the American Association of Anatomists Jan, 2011 | Pubmed ID: 21117147
The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function.
Circulation research Jan, 2011 | Pubmed ID: 21148430
Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin.
The Biochemical journal May, 2011 | Pubmed ID: 21306299
Activation of RhoA in podocytes induces focal segmental glomerulosclerosis.
Journal of the American Society of Nephrology : JASN Sep, 2011 | Pubmed ID: 21804090
Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes.
Journal of neuroscience research Jan, 2012 | Pubmed ID: 21887699
Podocyte Protein, Nephrin, Is a Substrate of Protein Tyrosine Phosphatase 1B.
Journal of signal transduction , 2011 | Pubmed ID: 22013520
Notch promotes dynamin-dependent endocytosis of nephrin.
Journal of the American Society of Nephrology : JASN Jan, 2012 | Pubmed ID: 22052054
University of Guelph
Steve P. Hawley*,1,
Melanie K. B. Wills*,1,
Nina Jones1
1Department of Molecular and Cellular Biology, University of Guelph
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