David Margulies

Binding of the natural killer cell inhibitory receptor Ly49A to its major histocompatibility complex class I ligand. Crucial contacts include both H-2Dd AND beta 2-microglobulin.

Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination.

MHC class I recognition by Ly49 natural killer cell receptors.

Crystal structure of the Ly49I natural killer cell receptor reveals variability in dimerization mode within the Ly49 family.

Bidentate ligation of heme analogues; novel biomimetics of peroxidase active site.

Rapid induction of apoptosis in CD8+ HIV-1 envelope-specific murine CTLs by short exposure to antigenic peptide.

A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen.

CD28, costimulator or agonist receptor?

Magnetic tuning of biquadratic exchange coupling in magnetic thin films.

Variable MHC class I engagement by Ly49 natural killer cell receptors demonstrated by the crystal structure of Ly49C bound to H-2K(b).

Molecular interactions: stiff or floppy (or somewhere in between?).

Spontaneous organ-specific Th2-mediated autoimmunity in TCR transgenic mice.

Resistance to viral infection by intraepithelial lymphocytes in HIV-1 P18-I10-specific T-cell receptor transgenic mice.

Chemical input multiplicity facilitates arithmetical processing.

Monoclonal antibodies: producing magic bullets by somatic cell hybridization.

Backbone and side chain resonance assignmentsof a TRAV14-3 mouse T cell receptor domain.

Fluorescein as a model molecular calculator with reset capability.

Crystal structure of the murine cytomegalovirus MHC-I homolog m144.

A molecular full-adder and full-subtractor, an additional step toward a moleculator.

A molecular keypad lock: a photochemical device capable of authorizing password entries.

Avidity of CD8 T cells sharpens immunodominance.

Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153.

Role of alpha3 domain of class I MHC molecules in the activation of high- and low-avidity CD8+ CTLs.

The TLR3 signaling complex forms by cooperative receptor dimerization.

Estimation of low frequency antigen-presenting cells with a novel RELISPOT assay.

Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage.

Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.

Protein recognition by an ensemble of fluorescent DNA G-quadruplexes.

The behavioral organization, temporal characteristics, and diagnostic concomitants of rage outbursts in child psychiatric inpatients.

Home schooling of NK cells.

A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens.

Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution.

Rages--what are they and who has them?

Digital analysis of protein properties by an ensemble of DNA quadruplexes.

Rages or temper tantrums? The behavioral organization, temporal characteristics, and clinical significance of angry-agitated outbursts in child psychiatry inpatients.

Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity.

Structural basis of the CD8 alpha beta/MHC class I interaction: focused recognition orients CD8 beta to a T cell proximal position.

Surface binding inhibitors of the SCF-KIT protein-protein interaction.

Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.

Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies.

Liquid risperidone in the treatment of rages in psychiatrically hospitalized children with possible bipolar disorder.

Combinatorial protein recognition as an alternative approach to antibody-mimetics.

Counterpoint: Do not opine before it's time.

How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance.

Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.

High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism.

Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity.

Will disruptive mood dysregulation disorder reduce false diagnosis of bipolar disorder in children?

The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.

Medication detection by a combinatorial fluorescent molecular sensor.

Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion.

A structural and molecular dynamics approach to understanding the peptide-receptive transition state of MHC-I molecules.

Authorizing multiple chemical passwords by a combinatorial molecular keypad lock.

Mutation of KCNJ8 in a patient with Cantú syndrome with unique vascular abnormalities - Support for the role of K(ATP) channels in this condition.

Callous-unemotional traits, proactive aggression, and treatment outcomes of aggressive children with attention-deficit/hyperactivity disorder.

Development of a scalable pharmacogenomic clinical decision support service.

iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls.

An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.

Targeted protein surface sensors as a tool for analyzing small populations of proteins in biological mixtures.

The in-betweeners: MAIT cells join the innate-like lymphocytes gang.

The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.

Enzyme-Artificial Enzyme Interactions as a Means for Discriminating among Structurally Similar Isozymes.

The cellular environment regulates in situ kinetics of T-cell receptor interaction with peptide major histocompatibility complex.

Protein-Protein Communication and Enzyme Activation Mediated by a Synthetic Chemical Transducer.

The Neuronal Migration Factor srGAP2 Achieves Specificity in Ligand Binding through a Two-Component Molecular Mechanism.

Sensing Protein Surfaces with Targeted Fluorescent Receptors.

Sensing Protein Surfaces with Targeted Fluorescent Receptors.

A Novel MHC-I Surface Targeted for Binding by the MCMV m06 Immunoevasin Revealed by Solution NMR.

Artificial signal transduction therapy: a futuristic approach to disease treatment.

William E. Paul 1936-2015.

Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures.

Prevalence and Treatment Outcomes of Persistent Negative Mood Among Children with Attention-Deficit/Hyperactivity Disorder and Aggressive Behavior.

Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing.

Orthogonal NGS for High Throughput Clinical Diagnostics.

Message in a molecule.

Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock.

Genetic Misdiagnoses and the Potential for Health Disparities.