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Deoxycholic acid conjugates are muscarinic cholinergic receptor antagonists.
Pharmacology Aug, 2002 | Pubmed ID: 12119452
Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist.
The Journal of pharmacology and experimental therapeutics Oct, 2002 | Pubmed ID: 12235229
Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line.
Biochimica et biophysica acta Oct, 2002 | Pubmed ID: 12379313
Selective interaction of bile acids with muscarinic receptors: a case of molecular mimicry.
European journal of pharmacology Dec, 2002 | Pubmed ID: 12464352
Activation of muscarinic receptor signaling by bile acids: physiological and medical implications.
Digestive diseases and sciences Aug, 2003 | Pubmed ID: 12924634
Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells.
Cancer research Oct, 2003 | Pubmed ID: 14583469
3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation.
Biochemical and biophysical research communications Apr, 2005 | Pubmed ID: 15721270
Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors.
Biochemical pharmacology Oct, 2005 | Pubmed ID: 16139803
Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line.
Biochemical pharmacology Apr, 2007 | Pubmed ID: 17222808
Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.
Journal of cellular physiology May, 2008 | Pubmed ID: 18064605
Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia.
Cancer research May, 2008 | Pubmed ID: 18483237
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation.
American journal of physiology. Gastrointestinal and liver physiology Sep, 2008 | Pubmed ID: 18653726
Muscarinic receptors and ligands in cancer.
American journal of physiology. Cell physiology Feb, 2009 | Pubmed ID: 19036940
Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis.
Experimental cell research Feb, 2009 | Pubmed ID: 19056378
Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells.
American journal of physiology. Gastrointestinal and liver physiology Apr, 2009 | Pubmed ID: 19221016
Scopolamine treatment and muscarinic receptor subtype-3 gene ablation augment azoxymethane-induced murine liver injury.
The Journal of pharmacology and experimental therapeutics Jun, 2010 | Pubmed ID: 20197374
In vivo magnetic resonance imaging to detect biliary excretion of 19F-labeled drug in mice.
Drug metabolism and disposition: the biological fate of chemicals May, 2011 | Pubmed ID: 21270105
Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion.
American journal of physiology. Gastrointestinal and liver physiology May, 2011 | Pubmed ID: 21273532
Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice.
Carcinogenesis Sep, 2011 | Pubmed ID: 21705482
Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells.
Biochemical and biophysical research communications Nov, 2011 | Pubmed ID: 22027145
Design and characterization of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile Acid transporter activity.
Pharmaceutical research May, 2013 | Pubmed ID: 23319170
Effects of modulating M3 muscarinic receptor activity on azoxymethane-induced liver injury in mice.
Biochemical pharmacology Jul, 2013 | Pubmed ID: 23707755
Bedside to bench: role of muscarinic receptor activation in ultrarapid growth of colorectal cancer in a patient with pheochromocytoma.
Mayo Clinic proceedings Nov, 2013 | Pubmed ID: 24100192
Phrygian Cap Appearance of a Mouse Gallbladder on Magnetic Resonance Imaging.
Journal of veterinary science & medical diagnosis Mar, 2013 | Pubmed ID: 24371838
Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia.
Molecular cancer , 2014 | Pubmed ID: 24694019
In vivo performance of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile acid transport.
Molecular pharmaceutics May, 2014 | Pubmed ID: 24708306
Design and evaluation of a novel trifluorinated imaging agent for assessment of bile acid transport using fluorine magnetic resonance imaging.
Journal of pharmaceutical sciences Nov, 2014 | Pubmed ID: 25196788
M1 muscarinic receptors modify oxidative stress response to acetaminophen-induced acute liver injury.
Free radical biology & medicine Jan, 2015 | Pubmed ID: 25452146
Slc10a2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids.
Carcinogenesis Oct, 2015 | Pubmed ID: 26210740
M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice.
Scientific reports Sep, 2015 | Pubmed ID: 26374068
Jessica Felton1,
Kunrong Cheng2,
Anan Said2,
Aaron C. Shang2,
Su Xu3,
Diana Vivian4,
Melissa Metry5,
James E. Polli5,
Jean-Pierre Raufman2,6
1Department of Surgery, University of Maryland School of Medicine,
2Department of Medicine, University of Maryland School of Medicine,
3Department of Radiology, University of Maryland School of Medicine,
4, Food and Drug Administration,
5Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy,
6, VA Maryland Health Care System
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