network-analysis-foramen-ovale-electrode-recordings-drug-resistant

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Approximately 30% of epilepsy patients are refractory to antiepileptic drugs. In these cases, surgery is the only alternative to eliminate/control ...

Instituto de Investigación Sanitaria Hospital de la Princesa

Fluorescence-guided resection (FGR) using 5-aminolevulinic acid (5-ALA) exhibits a potential risk of permanent neurological deficits that can be minimized using intraoperative neurophysiological monitoring (IONM). We assessed the role of IONM in FGR surgery in patients harboring tumors in or near eloquent areas.

Role of intraoperative neurophysiological monitoring during fluorescence-guided resection surgery.

The traditional surgical approach to treat drug-resistant focal epileptic patients is in the resection or disconnection of the epileptic focus. However, a significant minority of patients continue to experience seizures after surgery, which shows the incomplete level of knowledge that currently we have of this pathology.

[Functional connectivity and complex networks in focal epilepsy. Pathophysiology and therapeutic implications].

The ring chromosome 20 syndrome (r20) is a rare genetic disorder with a late diagnosis.

[Electroclinical characteristics of a patient with ring chromosome 20 syndrome].

INTRODUCTION. Surgery of arteriovenous malformations of eloquent areas has a significant risk of causing severe neurological deficits. CASE REPORT. A 39 years old woman having a headache, showed an arteriovenous malformation in right rolandic region. During resection, performed under general anesthesia, a neurophysiological mapping and subsequently intraoperative neurophysiological monitoring of motor and somatosensory functions was performed. The temporary closure of an artery resulted in a severe motor impairment, reversible after remove the clipping, so that artery had to be respected during the intervention. After resection, the motor and sensory responses were normal. The patient was discharged without any neurological deficits. CONCLUSION. Functional mapping and intraoperative neurophysiological monitoring were very helpful for the identification and protection of eloquent areas. The use of these techniques for resection of arteriovenous malformations located in functionally relevant areas, allows a safely surgery in patients under general anesthesia.

[Cortical mapping and neurophysiological monitoring during resection of an arteriovenous malformation in the rolandic region].

So far, a little is known about transition from normal to focal epileptic brain, although disruption in blood-brain barrier and albumin had recently involved. The main objective of this work is to characterize the response of cultured human astrocytes to plasma albumin, including induction of DNA synthesis. Cortical tissue was obtained from 9 patients operated from temporal lobe epilepsy. Astrocytes were cultured for 3-4 weeks and cytosolic calcium concentration ([Ca(2+)]c) was measured. Bovine and human plasma albumin were used. We observed that low albumin concentration decreases [Ca(2+)]c, while higher concentration, induces increase in [Ca(2+)]c. It was shown that increase in [Ca(2+)] c was mediated by inositol 1,4,5-trisphosphate and released from internal stores. Increase in [Ca(2+)]c was reduced to 19% by blocking the transforming growth factor-beta (TGF-βR) receptor. Albumin induces DNA synthesis in a dose-response manner. Finally, induction of DNA synthesis can be partially blocked by heparin and block of TGF-β; however, the combination of both incompletely inhibits DNA synthesis. Therefore, results suggest that mechanisms other than Ca(2+) signals and TGF-β receptor activation might induce DNA synthesis in a lesser degree. These results may be important to further understand the mechanisms involved in the transition from normal to focal epileptic brain.

Plasma albumin induces cytosolic calcium oscilations and DNA synthesis in human cultured astrocytes.

Interictal synchronization clusters have recently been described in several publications using diverse techniques, including neurophysiological recordings and fMRI, in patients suffering from epilepsy. However, little is known about the role of these hyper-synchronous areas during seizures. In this work, we report an analysis of synchronization clusters jointly with several network measures during seizure activity; we then discuss our findings in the context of prior literature.

Inhomogeneous cortical synchronization and partial epileptic seizures.

[Cortical mapping and neurophysiological monitoring during resection of an arteriovenous malformation in the rolandic region. Reply].

Etomidate mimics some typical epileptic neurophysiological features, such as the appearance of spikes and high frequency oscillations, when it is administrated to epileptic patients. However, little is known about its influence on the underlying cortical network. An assessment of comparable cortical dynamics between seizures and etomidate would allow for a more detailed study of the network parameters underlying the ictal stage by using etomidate as a proxy. The objective of the present work is to show that temporal lobe seizures produce network changes comparable to the ones elicited by etomidate administration.

Assessing the equivalence between etomidate and seizure network dynamics in temporal lobe epilepsy.

The current practice under which patients with refractory epilepsy are surgically treated is based mainly on the identification of specific cortical areas, mainly the epileptogenic zone, which is believed to be responsible for generation of seizures. A better understanding of the whole epileptic network and its components and properties is required before more effective and less invasive therapies can be developed. The aim of the present study was to partially characterize the evolution of the functional network during the preictal-ictal transition in partial seizures in patients with temporal lobe epilepsy (TLE).

Disrupted Ipsilateral Network Connectivity in Temporal Lobe Epilepsy.

[This corrects the article DOI: 10.1155/2014/539140.].

Lorena Vega-Zelaya

Clinical Neurophysiology & National Reference Unit for the Treatment of Refractory Epilepsy

Instituto de Investigación Sanitaria Hospital de la Princesa

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Lorena Vega-Zelaya

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Clinical Neurophysiology & National Reference Unit for the Treatment of Refractory Epilepsy

Instituto de Investigación Sanitaria Hospital de la Princesa

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Clinical Neurophysiology & National Reference Unit for the Treatment of Refractory Epilepsy