Kazuhiko Ishihara

Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine) grafted polyethylene: comparisons with the effect of polyethylene cross-linking and ceramic femoral heads.

Microfluidic flow control on charged phospholipid polymer interface.

Protective effects of the whisky congeners on ethanol-induced gastric mucosal damage.

Nanometer-scale patterned surfaces for control of cell adhesion.

A monoclonal antibody, PGM34, against 6-sulfated blood-group H type 2 antigen, on the carbohydrate moiety of mucin.

High lubricious surface of cobalt-chromium-molybdenum alloy prepared by grafting poly(2-methacryloyloxyethyl phosphorylcholine).

Feasibility of a tiny centrifugal blood pump (TinyPump) for pediatric extracorporeal circulatory support.

Effects of photo-induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on physical properties of cross-linked polyethylene in artificial hip joints.

Tissue-compatible and adhesive polyion complex hydrogels composed of amphiphilic phospholipid polymers.

Enhanced wear resistance of orthopaedic bearing due to the cross-linking of poly(MPC) graft chains induced by gamma-ray irradiation.

Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel.

Instantaneous determination via bimolecular recognition: usefulness of FRET in phosphorylcholine group enriched nanoparticles.

Effects of a novel histamine H2-receptor antagonist, lafutidine, on the mucus barrier of human gastric mucosa.

Effect of 2-methacryloyloxyethyl phosphorylcholine concentration on photo-induced graft polymerization of polyethylene in reducing the wear of orthopaedic bearing surface.

Bioconjugated phospholipid polymer biointerface for enzyme-linked immunosorbent assay.

Surface tethering of phosphorylcholine groups onto poly(dimethylsiloxane) through swelling--deswelling methods with phospholipids moiety containing ABA-type block copolymers.

Photografting of 2-methacryloyloxyethyl phosphorylcholine from polydimethylsiloxane: tunable protein repellency and lubrication property.

Polymer nanoparticles covered with phosphorylcholine groups and immobilized with antibody for high-affinity separation of proteins.

Prevention of biofilm formation with a coating of 2-methacryloyloxyethyl phosphorylcholine polymer.

Effect of tea catechins on body fat accumulation in rats fed a normal diet.

Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis.

Antithrombogenic properties of a monopivot magnetic suspension centrifugal pump for circulatory assist.

Effects of mobility/immobility of surface modification by 2-methacryloyloxyethyl phosphorylcholine polymer on the durability of polyethylene for artificial joints.

Establishing ultimate biointerfaces covered with phosphorylcholine groups.

Dimensions of a free linear polymer and polymer immobilized on silica nanoparticles of a zwitterionic polymer in aqueous solutions with various ionic strengths.

Rapid development of hydrophilicity and protein adsorption resistance by polymer surfaces bearing phosphorylcholine and naphthalene groups.

Protein adsorption resistance and oxygen permeability of chemically crosslinked phospholipid polymer hydrogel for ophthalmologic biomaterials.

Artificial cell membrane-covered nanoparticles embedding quantum dots as stable and highly sensitive fluorescence bioimaging probes.

Surface immobilization of biocompatible phospholipid polymer multilayered hydrogel on titanium alloy.

Changes in the mucus barrier of the rat during 5-fluorouracil-induced gastrointestinal mucositis.

Effects of tea catechins on the gastrointestinal mucosa in rats.

Superlubricious surface mimicking articular cartilage by grafting poly(2-methacryloyloxyethyl phosphorylcholine) on orthopaedic metal bearings.

Surface modification by 2-methacryloyloxyethyl phosphorylcholine coupled to a photolabile linker for cell micropatterning.

Suppression of protein adsorption on a charged phospholipid polymer interface.

Selective targeting by preS1 domain of hepatitis B surface antigen conjugated with phosphorylcholine-based amphiphilic block copolymer micelles as a biocompatible, drug delivery carrier for treatment of human hepatocellular carcinoma with paclitaxel.

Effects of combination treatment with famotidine and methylmethionine sulfonium chloride on the mucus barrier of rat gastric mucosa.

Evaluation of conditions for release of mucin-type oligosaccharides from glycoproteins by hydrazine gas treatment.

RAFT synthesis and stimulus-induced self-assembly in water of copolymers based on the biocompatible monomer 2-(methacryloyloxy)ethyl phosphorylcholine.

Effects of indomethacin on the rat small intestinal mucosa: immunohistochemical and biochemical studies using anti-mucin monoclonal antibodies.

Neutral cysteine protease bleomycin hydrolase is essential for the breakdown of deiminated filaggrin into amino acids.

Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry.

Development of targeted therapy with paclitaxel incorporated into EGF-conjugated nanoparticles.

Controllable nanostructured surface modification on quantum dot for biomedical application in aqueous medium.

Fabrication of a cell-adhesive protein imprinting surface with an artificial cell membrane structure for cell capturing.

Feasibility study of introducing redox property by modification of PMBN polymer for biofuel cell applications.

Second-generation histamine H(2)-receptor antagonists with gastric mucosal defensive properties.

Bioabsorbable material-containing phosphorylcholine group-rich surfaces for temporary scaffolding of the vessel wall.

Biodegradable polymer films for releasing nanovehicles containing sirolimus.

Conformational recovery and preservation of protein nature from heat-induced denaturation by water-soluble phospholipid polymer conjugation.

Development of a method to evaluate caspase-3 activity in a single cell using a nanoneedle and a fluorescent probe.

Protein adsorption and cell adhesion on cationic, neutral, and anionic 2-methacryloyloxyethyl phosphorylcholine copolymer surfaces.

Controlled drug release from multilayered phospholipid polymer hydrogel on titanium alloy surface.

Cell adhesion on phase-separated surface of block copolymer composed of poly(2-methacryloyloxyethyl phosphorylcholine) and poly(dimethylsiloxane).

Intraperitoneal administration of paclitaxel solubilized with poly(2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) for peritoneal dissemination of gastric cancer.

Surface modification of a titanium alloy with a phospholipid polymer prepared by a plasma-induced grafting technique to improve surface thromboresistance.

Nippostrongylus brasiliensis: increase of sialomucins reacting with anti-mucin monoclonal antibody HCM31 in rat small intestinal mucosa with primary infection and reinfection.

Nanoscale evaluation of lubricity on well-defined polymer brush surfaces using QCM-D and AFM.

Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage.

[Progress of research in osteoarthritis. Invention of longer lasting artificial joints].

Self-initiated surface grafting with poly(2-methacryloyloxyethyl phosphorylcholine) on poly(ether-ether-ketone).

Cell-penetrating macromolecules: direct penetration of amphipathic phospholipid polymers across plasma membrane of living cells.

Graft linker immobilization for spatial control of protein immobilization inside fused microchips.

Super-hydrophilic silicone hydrogels with interpenetrating poly(2-methacryloyloxyethyl phosphorylcholine) networks.

The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions.

Stabilization of phospholipid polymer surface with three-dimensional nanometer-scaled structure for highly sensitive immunoassay.

Vulnerable sites and changes in mucin in the rat small intestine after non-steroidal anti-inflammatory drugs administration.

Self-initiated surface graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on poly(ether ether ketone) by photoirradiation.

Phospholipid Polymer Biointerfaces for Lab-on-a-Chip Devices.

Novel polymer biomaterials and interfaces inspired from cell membrane functions.

An efficient surface modification using 2-methacryloyloxyethyl phosphorylcholine to control cell attachment via photochemical reaction in a microchannel.

A microfluidic hydrogel capable of cell preservation without perfusion culture under cell-based assay conditions.

2-Methacryloyloxyethyl phosphorylcholine polymer (MPC)-coating improves the transfection activity of GALA-modified lipid nanoparticles by assisting the cellular uptake and intracellular dissociation of plasmid DNA in primary hepatocytes.

Spontaneous Formation of a Hydrogel Composed of Water-Soluble Phospholipid Polymers Grafted with Enantiomeric Oligo(lactic acid) Chains.

Simple surface modification of a titanium alloy with silanated zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity.

Simple synthesis of a library of zwitterionic surfactants via Michael-type addition of methacrylate and alkane thiol compounds.

Reduction of protein adsorption on well-characterized polymer brush layers with varying chemical structures.

The biological performance of cell-containing phospholipid polymer hydrogels in bulk and microscale form.

Control of cell function on a phospholipid polymer having phenylboronic acid moiety.

Spatial distribution of intraperitoneally administrated paclitaxel nanoparticles solubilized with poly (2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) in peritoneal metastatic nodules.

Single-cell attachment and culture method using a photochemical reaction in a closed microfluidic system.

Effect of hydrophilic polymer conjugation on heat-induced conformational changes in a protein.

Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats.

Cartilage-mimicking, high-density brush structure improves wear resistance of crosslinked polyethylene: a pilot study.

Tissue response to poly(L-lactic acid)-based blend with phospholipid polymer for biodegradable cardiovascular stents.

Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis.

Reduction of Peritendinous adhesions by hydrogel containing biocompatible phospholipid polymer MPC for tendon repair.

Significance of antibody orientation unraveled: well-oriented antibodies recorded high binding affinity.

Well-controlled cationic water-soluble phospholipid polymer-DNA nanocomplexes for gene delivery.

In vivo evaluation of the "TinyPump" as a pediatric left ventricular assist device.

Hydrolyzed eggshell membrane immobilized on phosphorylcholine polymer supplies extracellular matrix environment for human dermal fibroblasts.

Plaunotol induces a comparative increase of acidic mucin fraction in gastric juice.

A bioconjugated phospholipid polymer biointerface with nanometer-scaled structure for highly sensitive immunoassays.

Methacrylate polymer layers bearing poly(ethylene oxide) and phosphorylcholine side chains as non-fouling surfaces: in vitro interactions with plasma proteins and platelets.

Effects of 3,4-dihydrophenyl groups in water-soluble phospholipid polymer on stable surface modification of titanium alloy.

Photodynamic therapy using an anti-EGF receptor antibody complexed with verteporfin nanoparticles: a proof of concept study.

Preparation and surface properties of polyrotaxane-containing tri-block copolymers as a design for dynamic biomaterials surfaces.

Cell adhesion control on photoreactive phospholipid polymer surfaces.

Regulation of cell proliferation by multi-layered phospholipid polymer hydrogel coatings through controlled release of paclitaxel.

Expression of bleomycin hydrolase in keratinization disorders.

Association of gastric acid and mucus secretion level with low-dose aspirin-induced gastropathy.

Mechanical force-based probing of intracellular proteins from living cells using antibody-immobilized nanoneedles.

Degradable thermoresponsive nanogels for protein encapsulation and controlled release.

Spherical phospholipid polymer hydrogels for cell encapsulation prepared with a flow-focusing microfluidic channel device.

Rapid and specific alterations of goblet cell mucin in rat airway and small intestine associated with resistance against Nippostrongylus brasiliensis reinfection.

Essential role of gastric gland mucin in preventing gastric cancer in mice.

Different effects of two types of H2-receptor antagonists, famotidine and roxatidine, on the mucus barrier of rat gastric mucosa.

Fabrication of polymeric electron-transfer mediator/enzyme hydrogel multilayer on an Au electrode in a layer-by-layer process.

In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats.

Biomimetic hydrogels gate transport of calcium ions across cell culture inserts.

Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials.

Wettability and antifouling behavior on the surfaces of superhydrophilic polymer brushes.

Simple surface treatment using amphiphilic phospholipid polymers to obtain wetting and lubricity on polydimethylsiloxane-based substrates.

Electrospun phospholipid polymer substrate for enhanced performance in immunoassay system.

Evaluation of the actin cytoskeleton state using an antibody-functionalized nanoneedle and an AFM.

Direct observation of selective protein capturing on molecular imprinting substrates.

Impact of the nature, size and chain topologies of carbohydrate-phosphorylcholine polymeric gene delivery systems.

The helical flow pump with a hydrodynamic levitation impeller.

The effect of the encapsulation of bacteria in redox phospholipid polymer hydrogels on electron transfer efficiency in living cell-based devices.

Direct electron transfer with enzymes on nanofiliform titanium oxide films with electron-transport ability.

Redox phospholipid polymer microparticles as doubly functional polymer support for immobilization of enzyme oxidase.

Detachment of cells adhered on the photoreactive phospholipid polymer surface by photoirradiation and their functionality.

The significance of hydrated surface molecular mobility in the control of the morphology of adhering fibroblasts.

Inducing rapid cellular response on RGD-binding threaded macromolecular surfaces.

Hybridization of poly(2-methacryloyloxyethyl phosphorylcholine-block-2-ethylhexyl methacrylate) with segmented polyurethane for reducing thrombogenicity.

A simple procedure for the preparation of precise spatial multicellular phospholipid polymer hydrogels.

Extracellular electron transfer across bacterial cell membranes via a cytocompatible redox-active polymer.

The monoclonal antibody HCM31 specifically recognises the Sd(a) tetrasaccharide in goblet cell mucin.

Grafting of poly(2-methacryloyloxyethyl phosphorylcholine) on polyethylene liner in artificial hip joints reduces production of wear particles.

The use of the mechanical microenvironment of phospholipid polymer hydrogels to control cell behavior.

Surface modification of a biodegradable magnesium alloy with phosphorylcholine (PC) and sulfobetaine (SB) functional macromolecules for reduced thrombogenicity and acute corrosion resistance.

Reduced platelets and bacteria adhesion on poly(ether ether ketone) by photoinduced and self-initiated graft polymerization of 2-methacryloyloxyethyl phosphorylcholine.

A large mobility of hydrophilic molecules at the outmost layer controls the protein adsorption and adhering behavior with the actin fiber orientation of human umbilical vein endothelial cells (HUVEC).

Preparation and characterization of polyion complex micelles with phosphobetaine shells.

Poly(ether-ether-ketone) orthopedic bearing surface modified by self-initiated surface grafting of poly(2-methacryloyloxyethyl phosphorylcholine).

Detection of microtubules in vivo using antibody-immobilized nanoneedles.

Elastic repulsion from polymer brush layers exhibiting high protein repellency.

Synthesis of photoreactive phospholipid polymers for use in versatile surface modification of various materials to obtain extreme wettability.

Increased gastric mucus secretion alleviates non-steroidal anti-inflammatory drug-induced abdominal pain.

The helical flow total artificial heart: implantation in goats.

Effect of UV-irradiation intensity on graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on orthopedic bearing substrate.

Long-term hip simulator testing of the artificial hip joint bearing surface grafted with biocompatible phospholipid polymer.

Cell-membrane-permeable and cytocompatible phospholipid polymer nanoprobes conjugated with molecular beacons.

Quantitating distance-dependent, indirect cell-cell interactions with a multilayered phospholipid polymer hydrogel.

Identification and characterization of sulfated carbohydrate-binding protein from Lactobacillus reuteri.

Effects of molecular architecture of phospholipid polymers on surface modification of segmented polyurethanes.

Comprehensive genetic analysis of early host body reactions to the bioactive and bio-inert porous scaffolds.

Changes in the mucus barrier during cisplatin-induced intestinal mucositis in rats.

Evaluation of the durability and antiadhesive action of 2-methacryloyloxyethyl phosphorylcholine grafting on an acrylic resin denture base material.

Calcium mediated formation of phosphorylcholine-based polyplexes for efficient knockdown of epidermal growth factor receptors (EGFR) in HeLa cells.

Quantitative evaluation of interaction force between functional groups in protein and polymer brush surfaces.

Regulation of the cyanobacterial circadian clock by electrochemically controlled extracellular electron transfer.

Biomimetic interfaces reveal activation dynamics of C-reactive protein in local microenvironments.

Poly(2-methacryloyloxyethyl phosphorylcholine) grafting and vitamin E blending for high wear resistance and oxidative stability of orthopedic bearings.

Durable modification of segmented polyurethane for elastic blood-contacting devices by graft-type 2-methacryloyloxyethyl phosphorylcholine copolymer.

Water-soluble polymers bearing phosphorylcholine group and other zwitterionic groups for carrying DNA derivatives.

Quantitative evaluation of interaction force of fibrinogen at well-defined surfaces with various structures.

Phospholipid polymer-based antibody immobilization for cell rolling surfaces in stem cell purification system.

Gene chip/PCR-array analysis of tissue response to 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer surfaces in a mouse subcutaneous transplantation system.

Zwitterion biomaterials. Foreword.

Clinical and radiographic outcomes of total hip replacement with poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners: three-year results of a prospective consecutive series.

Evaluation of bifidobacterial adhesion to acidic sugar chains of porcine colonic mucins.

Neutron reflectivity study of the swollen structure of polyzwitterion and polyeletrolyte brushes in aqueous solution.

Multidirectional wear and impact-to-wear tests of phospholipid-polymer-grafted and vitamin E-blended crosslinked polyethylene: a pilot study.

Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions.

Concentration-dependent effects of fibronectin adsorbed on hydroxyapatite surfaces on osteoblast adhesion.

Hollow fiber membrane modification with functional zwitterionic macromolecules for improved thromboresistance in artificial lungs.

Safety, reliability, and operability of cochlear implant electrode arrays coated with biocompatible polymer.

Molecular interaction forces generated during protein adsorption to well-defined polymer brush surfaces.

Wear resistance of the biocompatible phospholipid polymer-grafted highly cross-linked polyethylene liner against larger femoral head.

Synthesis of grafted phosphorylcholine polymer layers as specific recognition ligands for C-reactive protein focused on grafting density and thickness to achieve highly sensitive detection.

Induction of Sd(a)-sialomucin and sulfated H-sulfomucin in mouse small intestinal mucosa by infection with parasitic helminth.

Therapeutic effect of intravesical administration of paclitaxel solubilized with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) in an orthotopic bladder cancer model.

Efficient differentiation of stem cells encapsulated in a cytocompatible phospholipid polymer hydrogel with tunable physical properties.

Preparation of upper critical solution temperature (UCST) responsive diblock copolymers bearing pendant ureido groups and their micelle formation behavior in water.

Influences of dehydration and rehydration on the lubrication properties of phospholipid polymer-grafted cross-linked polyethylene.

Prevention of bacterial adhesion and biofilm formation on a vitamin E-blended, cross-linked polyethylene surface with a poly(2-methacryloyloxyethyl phosphorylcholine) layer.

Effects of extra irradiation on surface and bulk properties of PMPC-grafted cross-linked polyethylene.

Photoreactive Polymers Bearing a Zwitterionic Phosphorylcholine Group for Surface Modification of Biomaterials.

Animal Experiments of the Helical Flow Total Artificial Heart.

Preparation of photoreactive phospholipid polymer nanoparticles to immobilize and release protein by photoirradiation.

Surface functionalization of quantum dots with fine-structured pH-sensitive phospholipid polymer chains.

Fabrication of a live cell-containing multilayered polymer hydrogel membrane with micrometer-scale thickness to evaluate pharmaceutical activity.

Spontaneous Packaging and Hypothermic Storage of Mammalian Cells with a Cell-Membrane-Mimetic Polymer Hydrogel in a Microchip.

Effects of Surface Modification and Bulk Geometry on the Biotribological Behavior of Cross-Linked Polyethylene: Wear Testing and Finite Element Analysis.

Preparation of a thick polymer brush layer composed of poly(2-methacryloyloxyethyl phosphorylcholine) by surface-initiated atom transfer radical polymerization and analysis of protein adsorption resistance.

Photoinduced inhibition of DNA unwinding in vitro with water-soluble polymers containing both phosphorylcholine and photoreactive groups.

Formation of Polyion Complex (PIC) Micelles and Vesicles with Anionic pH-Responsive Unimer Micelles and Cationic Diblock Copolymers in Water.

High-efficiency preparation of poly(2-methacryloyloxyethyl phosphorylcholine) grafting layer on poly(ether ether ketone) by photoinduced and self-initiated graft polymerization in an aqueous solution in the presence of inorganic salt additives.

Special issue on Zwitterionic Materials.

Discrimination of rat Brunner's gland carbohydrate antigens by site-specific monoclonal antibodies.

Diffusion-Induced Hydrophilic Conversion of Polydimethylsiloxane/Block-Type Phospholipid Polymer Hybrid Substrate for Temporal Cell-Adhesive Surface.

Precise control of surface electrostatic forces on polymer brush layers with opposite charges for resistance to protein adsorption.

Photoreactive Initiator for Surface-Initiated ATRP on Versatile Polymeric Substrates.

A hydrated phospholipid polymer-grafted layer prevents lipid-related oxidative degradation of cross-linked polyethylene.

Movement of a Quantum Dot Covered with Cytocompatible and pH-Responsible Phospholipid Polymer Chains under a Cellular Environment.

Reduced blood cell adhesion on polypropylene substrates by a simple surface zwitterionization.

Clinical safety and wear resistance of the phospholipid polymer-grafted highly cross-linked polyethylene liner.

Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces.

Focus on nanomedicine molecular science.

Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within cells.