Frank Reimann

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells.

Glucose-sensing in glucagon-like peptide-1-secreting cells.

Sulfonylurea stimulation of insulin secretion.

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.

Differential selectivity of insulin secretagogues: mechanisms, clinical implications, and drug interactions.

A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line.

A novel missense mutation in AE1 causing autosomal dominant distal renal tubular acidosis retains normal transport function but is mistargeted in polarized epithelial cells.

Open to control--new hope for patients with neonatal diabetes.

Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice.

Relapsing diabetes can result from moderately activating mutations in KCNJ11.

Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide traffic.

Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing.

An SCN9A channelopathy causes congenital inability to experience pain.

No differences in mortality between users of pancreatic-specific and non-pancreatic-specific sulphonylureas: a cohort analysis.

Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis.

Dissociation between sensing and metabolism of glucose in sugar sensing neurones.

Nutritional regulation of glucagon-like peptide-1 secretion.

Glucose sensing in L cells: a primary cell study.

Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.

TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor.

Molecular mechanisms underlying nutrient-stimulated incretin secretion.

Increased liver stiffness in alcoholic liver disease: differentiating fibrosis from steatohepatitis.

Molecular mechanisms underlying nutrient detection by incretin-secreting cells.

Pain perception is altered by a nucleotide polymorphism in SCN9A.

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.

Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like Peptide 1 neurons.

Congenital insensitivity to pain: novel SCN9A missense and in-frame deletion mutations.

Role of phosphodiesterase and adenylate cyclase isozymes in murine colonic glucagon-like peptide 1 secreting cells.

Glutamine triggers and potentiates glucagon-like peptide-1 secretion by raising cytosolic Ca2+ and cAMP.

CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.

Nutrient detection by incretin hormone secreting cells.

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.

Intestinal sensing of nutrients.

G-protein-coupled receptors in intestinal chemosensation.

Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry.

Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract.

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.

The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells.

Molecular mechanisms of incretin hormone secretion.

Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor.

A tag to track short chain fatty acid sensors.

Generation of L cells in mouse and human small intestine organoids.

Towards the harnessing of gut feelings.

Identification and characterization of GLP-1 receptor-expressing cells using a new transgenic mouse model.

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.

Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans.

Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.

LKB1 and AMPK differentially regulate pancreatic β-cell identity.

GLP-1 receptor stimulation of the lateral parabrachial nucleus reduces food intake: neuroanatomical, electrophysiological, and behavioral evidence.

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose.

Na+ current properties in islet α- and β-cells reflect cell-specific Scn3a and Scn9a expression.

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.

The role of gut endocrine cells in control of metabolism and appetite.

Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1.

Clocking up GLP-1: considering intestinal rhythms in the incretin effect.

The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells.

Targeting development of incretin-producing cells increases insulin secretion.

Gut chemosensing mechanisms.

Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.

Activation of the GLP-1 receptors in the nucleus of the solitary tract reduces food reward behavior and targets the mesolimbic system.

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.

Submembrane ATP and Ca2+ kinetics in α-cells: unexpected signaling for glucagon secretion.

Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations.

Transcriptional regulator PRDM12 is essential for human pain perception.

Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults.

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells.

Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells.

High fat diet impairs the function of glucagon-like peptide-1 producing L-cells.

Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells.

Corrigendum: Transcriptional regulator PRDM12 is essential for human pain perception.

A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors.

Can encapsulated glutamine increase GLP-1 secretion, improve glucose tolerance, and reduce meal size in healthy volunteers? A randomised, placebo-controlled, cross-over trial.

The effect of bariatric surgery on gastrointestinal and pancreatic peptide hormones.

Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium.

GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness.

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain.

The effect of encapsulated glutamine on gut peptide secretion in human volunteers.

Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.

G protein-coupled receptors as new therapeutic targets for type 2 diabetes.

Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells.

Stimulation of incretin secreting cells.

The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel.

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion.

Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.

Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion.

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.

Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia.

Gut Hormone Regulation and Secretion via FFA1 and FFA4.

Scaling it down: new in vitro tools to get the balance right.

Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight.

Signalling in the gut endocrine axis.